TBC1D22B and ARHGEF9

Data Source:
BioGRID (two hybrid)

		TBC1D22B	ARHGEF9
Description		TBC1 domain family member 22B	Cdc42 guanine nucleotide exchange factor 9
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GO Annotations	Cellular Component		Cytosol Postsynaptic Density
	Molecular Function	GTPase Activator Activity Protein Binding 14-3-3 Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Intracellular Protein Transport Activation Of GTPase Activity Regulation Of Cilium Assembly	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events GABA receptor activation GABA receptor activation
Drugs
Diseases			Hyperekplexia Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Acne (severe) ( 24927181) Blood glucose levels ( 31928498) Platelet count ( 27863252) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498)	Male-pattern baldness ( 28196072)
Interacting Genes		58 interacting genes: AP1B1 ARHGEF9 BLZF1 CALCOCO2 CARD10 CCDC57 CCDC88B CDR2 CEP63 CEP70 COG6 DAPK1 DDIT4L DEUP1 EFHC2 EXOC8 FHL3 FXR1 FXR2 GFAP GOLGA2 HMG20A HOMER3 HOOK2 HSD17B14 IKZF3 KIFC3 KRT34 KRT40 LHX8 LIMS1 LRRK2 MFHAS1 MID2 MTUS2 PICK1 PLEKHG4 PNMA5 RBM10 RBM48 REL SIAH1 SLAIN1 SORBS3 SPATA2 TACC3 TEPSIN TEX11 TP53BP2 TRIM23 TRIM27 TRIM54 TRIP6 VPS52 ZFP90 ZNF438 ZNF76 ZSCAN4	11 interacting genes: BCL6 CDC42 FAM90A1 GPHN IHO1 KHDRBS1 PLEKHA5 SMURF1 TBC1D22B TFIP11 TSGA10IP
Entrez ID		55633	23229
HPRD ID		15475	02337
Ensembl ID		ENSG00000065491	ENSG00000131089
Uniprot IDs		Q9NU19	B1AMR3 O43307
PDB IDs		6D0S	2YSQ
Enriched GO Terms of Interacting Partners?
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