ARHGEF9 and GPHN

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		ARHGEF9	GPHN
Description		Cdc42 guanine nucleotide exchange factor 9	gephyrin
Image
GO Annotations	Cellular Component	Cytosol Postsynaptic Density	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Dendrite Postsynaptic Membrane Synaptic Membrane Anchored Component Of Synaptic Membrane Postsynaptic Specialization Postsynaptic Specialization Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding ATP Binding Nitrate Reductase Activity Identical Protein Binding Molybdopterin Cofactor Binding Metal Ion Binding Molybdopterin Adenylyltransferase Activity Molybdopterin Molybdotransferase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Mo-molybdopterin Cofactor Biosynthetic Process Establishment Of Synaptic Specificity At Neuromuscular Junction Response To Metal Ion Molybdenum Incorporation Into Molybdenum-molybdopterin Complex Molybdopterin Cofactor Biosynthetic Process Glycine Receptor Clustering Gamma-aminobutyric Acid Receptor Clustering Postsynaptic Neurotransmitter Receptor Diffusion Trapping
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events GABA receptor activation GABA receptor activation	Molybdenum cofactor biosynthesis
Drugs			Formic acid Imidazole Propanoic acid
Diseases		Hyperekplexia Early infantile epileptic encephalopathy; Ohtahara syndrome	Hyperekplexia
GWAS		Male-pattern baldness ( 28196072)	Depression (quantitative trait) ( 23290196) Pneumococcal meningitis ( 31092817) Tandem gait ( 26219847) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		11 interacting genes: BCL6 CDC42 FAM90A1 GPHN IHO1 KHDRBS1 PLEKHA5 SMURF1 TBC1D22B TFIP11 TSGA10IP	15 interacting genes: ACADVL ARHGEF9 DYNLL1 DYNLL2 ENAH GABARAP GLRB KHDRBS1 MITD1 MTOR PFN1 PIN1 PSMA1 SPATS1 TUBA4A
Entrez ID		23229	10243
HPRD ID		02337	04893
Ensembl ID		ENSG00000131089	ENSG00000171723
Uniprot IDs		B1AMR3 O43307	Q9NQX3
PDB IDs		2YSQ	1JLJ
Enriched GO Terms of Interacting Partners?
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