TBC1D22B and PLEKHG4

Data Source:
BioGRID (two hybrid)

		TBC1D22B	PLEKHG4
Description		TBC1 domain family member 22B	pleckstrin homology and RhoGEF domain containing G4
Image			No pdb structure
GO Annotations	Cellular Component
	Molecular Function	GTPase Activator Activity Protein Binding 14-3-3 Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Intracellular Protein Transport Activation Of GTPase Activity Regulation Of Cilium Assembly	Regulation Of Catalytic Activity
Pathways
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Blood glucose levels ( 31928498) Platelet count ( 27863252) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498)	Blood protein levels ( 29875488 28240269) Heel bone mineral density ( 28869591) Refractive error ( 32231278)
Interacting Genes		58 interacting genes: AP1B1 ARHGEF9 BLZF1 CALCOCO2 CARD10 CCDC57 CCDC88B CDR2 CEP63 CEP70 COG6 DAPK1 DDIT4L DEUP1 EFHC2 EXOC8 FHL3 FXR1 FXR2 GFAP GOLGA2 HMG20A HOMER3 HOOK2 HSD17B14 IKZF3 KIFC3 KRT34 KRT40 LHX8 LIMS1 LRRK2 MFHAS1 MID2 MTUS2 PICK1 PLEKHG4 PNMA5 RBM10 RBM48 REL SIAH1 SLAIN1 SORBS3 SPATA2 TACC3 TEPSIN TEX11 TP53BP2 TRIM23 TRIM27 TRIM54 TRIP6 VPS52 ZFP90 ZNF438 ZNF76 ZSCAN4	65 interacting genes: A1CF ARHGEF5 ARMC7 BEX2 CCDC120 CCDC187 CDC42 CDKN2C CHIC2 COIL DCUN1D5 DPPA3 DTX2 DUSP13 FAM161A FGD2 GATA3 GCM2 GSTZ1 HCK HOXB9 HOXC8 KRT3 KRT75 MALSU1 MATR3 MDFI METAP1 MSRB3 MTA1 MYEF2 MYOZ1 NATD1 OTX1 PFKFB1 PKP2 PPP1R32 PRPF18 PRPF31 PSMB1 RHOA RIN1 SAXO1 SETD5 SH2D4A SHISA6 SIX1 SMCP SMG9 TBC1D22B TBX18 TEKT3 TENT5D TFAP2D TFG TRIM55 TRIM63 TSSK3 TTC23 USP2 VPS37C ZCCHC14 ZNF148 ZNF319 ZNF648
Entrez ID		55633	25894
HPRD ID		15475	10890
Ensembl ID		ENSG00000065491	ENSG00000196155
Uniprot IDs		Q9NU19	A0A024R6X4 Q58EX7
PDB IDs		6D0S
Enriched GO Terms of Interacting Partners?
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