PFDN1 and RMI1

Data Source:
BioGRID (two hybrid)

		PFDN1	RMI1
Description		prefoldin subunit 1	RecQ mediated genome instability 1
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GO Annotations	Cellular Component	Cytoplasm Prefoldin Complex	Nucleoplasm Nuclear Body RecQ Family Helicase-topoisomerase III Complex
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding	Nucleotide Binding Protein Binding
	Biological Process	Protein Folding Negative Regulation Of Amyloid Fibril Formation	Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination Reduction Of Food Intake In Response To Dietary Excess DNA Replication Response To Glucose Multicellular Organism Growth Glucose Homeostasis Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Childhood body mass index ( 33045005) Menarche (age at onset) ( 27182965 25231870) Molar-incisor hypomineralization ( 23918034) Response to statin therapy ( 20339536) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking initiation ( 30617275) Smoking status (ever vs never smokers) ( 30643258) Triglycerides ( 30275531)
Interacting Genes		54 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235	5 interacting genes: FANCM HSPA13 NR1H2 PFDN1 UBE3A
Entrez ID		5201	80010
HPRD ID		05357	09867
Ensembl ID		ENSG00000113068	ENSG00000178966
Uniprot IDs		O60925	Q9H9A7
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD	3MXN 3NBH 3NBI 4CGY 4CHT 4DAY
Enriched GO Terms of Interacting Partners?
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