PFDN1 and JADE1

Data Source:
BioGRID (two hybrid)

		PFDN1	JADE1
Description		prefoldin subunit 1	jade family PHD finger 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Prefoldin Complex	Histone Acetyltransferase Complex Nucleus Nucleoplasm Chromosome Cytoplasm Plasma Membrane Nuclear Speck Ciliary Basal Body
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding	Transcription Coactivator Activity Protein Binding Metal Ion Binding
	Biological Process	Protein Folding Negative Regulation Of Amyloid Fibril Formation	Apoptotic Process Negative Regulation Of Cell Growth Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	HATs acetylate histones
Drugs
Diseases
GWAS		Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)	Arterial stiffness index ( 31235810) Bone mineral density (total hip) ( 29883787)
Interacting Genes		54 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235	15 interacting genes: AKT1 CTNNB1 H3C14 H4C1 HMOX2 PFDN1 SEPTIN8 SMN1 TK1 UBE2E1 UBE2H UBE3A VHL YJU2 ZNF148
Entrez ID		5201	79960
HPRD ID		05357	10151
Ensembl ID		ENSG00000113068	ENSG00000077684
Uniprot IDs		O60925	B4E2E2 Q6IE81
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD
Enriched GO Terms of Interacting Partners?
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