PFDN1 and SEC31A

Data Source:
BioGRID (two hybrid)

		PFDN1	SEC31A
Description		prefoldin subunit 1	SEC31 homolog A, COPII coat complex component
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GO Annotations	Cellular Component	Cytoplasm Prefoldin Complex	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Vesicle Coat COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding	Structural Molecule Activity Protein Binding Calcium-dependent Protein Binding
	Biological Process	Protein Folding Negative Regulation Of Amyloid Fibril Formation	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II IRE1-mediated Unfolded Protein Response COPII Vesicle Coating Response To Calcium Ion COPII-coated Vesicle Cargo Loading
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	COPII-mediated vesicle transport MHC class II antigen presentation XBP1(S) activates chaperone genes Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)	Adult asthma ( 27611488) Neutrophil percentage of white cells ( 27863252)
Interacting Genes		54 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235	14 interacting genes: APC ARIH1 FHL5 KLHL12 MYOM2 PDCD6 PEF1 PFDN1 PRNP REL SEC13 TNNT1 TSC22D2 USP8
Entrez ID		5201	22872
HPRD ID		05357	15314
Ensembl ID		ENSG00000113068	ENSG00000138674
Uniprot IDs		O60925	A0A024RDH6 A1LU61 O94979
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD	3WXA
Enriched GO Terms of Interacting Partners?
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