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PFDN1 and ACTB
Data Source:
HPRD
(in vitro, in vivo)
PFDN1
ACTB
Description
prefoldin subunit 1
actin beta
Image
GO Annotations
Cellular Component
Cytoplasm
Prefoldin Complex
Chromatin
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Cell-cell Junction
Adherens Junction
Focal Adhesion
Actin Cytoskeleton
Membrane
Lamellipodium
Axon
Vesicle
Protein-containing Complex
NuA4 Histone Acetyltransferase Complex
Cytoplasmic Ribonucleoprotein Granule
Apical Junction Complex
Synapse
Extracellular Exosome
Tight Junction
Blood Microparticle
Dense Body
Presynapse
Postsynaptic Actin Cytoskeleton
Glutamatergic Synapse
Ribonucleoprotein Complex
Molecular Function
Amyloid-beta Binding
Protein Binding
Protein Folding Chaperone
Unfolded Protein Binding
Structural Constituent Of Cytoskeleton
Protein Binding
ATP Binding
Kinesin Binding
Protein Kinase Binding
Tat Protein Binding
Nucleosomal DNA Binding
Identical Protein Binding
Tau Protein Binding
Nitric-oxide Synthase Binding
Structural Constituent Of Postsynaptic Actin Cytoskeleton
Biological Process
Protein Folding
Negative Regulation Of Amyloid Fibril Formation
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Morphogenesis Of A Polarized Epithelium
Retina Homeostasis
Establishment Or Maintenance Of Cell Polarity
Axonogenesis
Protein Deubiquitination
Substantia Nigra Development
Regulation Of Transmembrane Transporter Activity
Negative Regulation Of Protein Binding
Cell Junction Assembly
Adherens Junction Assembly
Maintenance Of Blood-brain Barrier
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
ATP-dependent Chromatin Remodeling
Apical Protein Localization
Positive Regulation Of Gene Expression, Epigenetic
Ephrin Receptor Signaling Pathway
Cell Motility
Regulation Of Norepinephrine Uptake
Positive Regulation Of Norepinephrine Uptake
Membrane Organization
Platelet Aggregation
Protein Localization To Adherens Junction
Cellular Response To Cytochalasin B
Postsynaptic Actin Cytoskeleton Organization
Regulation Of Transepithelial Transport
Regulation Of Protein Localization To Plasma Membrane
Pathways
Prefoldin mediated transfer of substrate to CCT/TriC
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Gap junction degradation
Formation of annular gap junctions
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
HATs acetylate histones
Prefoldin mediated transfer of substrate to CCT/TriC
Folding of actin by CCT/TriC
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
Adherens junctions interactions
Adherens junctions interactions
Recycling pathway of L1
Recycling pathway of L1
VEGFA-VEGFR2 Pathway
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Cell-extracellular matrix interactions
B-WICH complex positively regulates rRNA expression
RHO GTPases activate IQGAPs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
MAP2K and MAPK activation
UCH proteinases
DNA Damage Recognition in GG-NER
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Clathrin-mediated endocytosis
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
Drugs
Quercetin
Phenethyl Isothiocyanate
Diseases
Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS
Alzheimer's disease (
28183528
)
Alzheimer's disease in APOE e4- carriers (
25778476
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Reaction time (
29844566
)
Global electrical heterogeneity phenotypes (
29622589
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Lymphocyte counts (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular hemoglobin concentration (
32888494
)
Monocyte count (
32888494
)
Relative hand skill in reading disability (
24068947
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Triglyceride levels (
32203549
)
Interacting Genes
54 interacting genes:
ACTA1
ACTB
ALB
BRK1
CCDC85A
CEP126
CHGA
DCTN1
DEFA1
DMAP1
EDRF1
EIF3C
EIF4A2
EOMES
ESS2
EXT2
EZH2
FAM20C
GET3
GIT1
GPRASP1
HAP1
HIP1
HMGXB3
HOXD8
IFT140
IMMT
INPP5K
JADE1
KIAA0408
LRIF1
MED31
NDC80
NR2F1
PDE4DIP
PDHB
PFDN2
PLXNB2
PRKD2
PSME1
PTN
RMI1
RPLP1
RPS28
SEC31A
SKP2
SNX5
SPTBN4
SUMO3
SYNDIG1
TERT
TTC38
YEATS4
ZNF235
157 interacting genes:
A2M
ABLIM1
ABRA
ACD
ACTC1
ACTG1
AIMP2
ALOX5
ANXA7
AQP2
AR
ARPC1B
ATF7IP
BBS4
BCL2L1
CAP1
CAPZA1
CCN2
CCT2
CCT4
CCT5
CCT8
CDC37
CDK5R2
CDKN1A
CDKN2A
CFL1
CFL2
CLIC4
CLNS1A
CNN2
CORO1A
CORO7
COTL1
CPNE1
CPNE2
CPNE4
CSNK1A1
CSNK2B
DMTN
DNASE1
DSTN
DUSP19
DYNLL1
EEF1A1
EHHADH
EMD
EP300
ERG
EZR
FABP4
FHL3
FLII
GAPDH
GNA12
GSN
H2AX
HCK
HIP1R
HMMR
HNRNPAB
HNRNPD
HNRNPU
HSD17B4
HSPB2
HTR6
KHDRBS1
LASP1
LGALS13
LINC01554
LINC02582
LMNA
LMOD1
LRRK2
LYN
MAP1B
MAP2
MAPT
MRGBP
MTNR1A
MX1
MYO18B
MYO1E
MYOC
NCALD
NCF1
NDEL1
NEBL
NOS2
NRAP
NSMAF
NT5E
NTAQ1
P2RX7
PCYT1A
PDIA2
PDLIM5
PFDN1
PFDN4
PFN1
PFN2
PHACTR4
PLD1
PLD2
PLG
POLR2A
POT1
PRKCD
PROSER2
PTN
PTPRF
RAB4A
RAC1
RAC2
RCC1
RNF4
RPL10A
S100A11
SAMHD1
SCN10A
SHBG
SMAD3
SMAD9
SMARCA4
SMN1
SPTAN1
SPTB
SPTBN2
SRPK2
SSH1
SSH2
SSH3
STX4
SUMO2
SYNJ2BP
TANC1
TGM2
TINF2
TK1
TMSB4X
TMSB4XP1
TMSB4XP4
TNNI2
TPM1
TPM2
TPM3
TRIM15
TSHR
TTR
UBE2I
UBE3A
VHL
VSNL1
WASF1
WASF2
WASF3
XPO6
Entrez ID
5201
60
HPRD ID
05357
00032
Ensembl ID
ENSG00000113068
ENSG00000075624
Uniprot IDs
O60925
P60709
Q1KLZ0
PDB IDs
6NR8
6NR9
6NRB
6NRC
6NRD
3BYH
3D2U
3J82
3LUE
6ANU
6ICT
6ICV
6LTJ
6MBJ
6MBK
6MBL
6NBW
6OX0
6OX1
6OX2
6OX3
6OX4
6OX5
Enriched GO Terms of Interacting Partners
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