PFDN1 and FAM20C

Data Source:
BioGRID (two hybrid)

		PFDN1	FAM20C
Description		prefoldin subunit 1	FAM20C golgi associated secretory pathway kinase
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GO Annotations	Cellular Component	Cytoplasm Prefoldin Complex	Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Phosphotransferase Activity, Alcohol Group As Acceptor Manganese Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Folding Negative Regulation Of Amyloid Fibril Formation	Protein Phosphorylation Biomineral Tissue Development Post-translational Protein Modification Cellular Protein Metabolic Process ATP Metabolic Process Enamel Mineralization Odontoblast Differentiation
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases			Raine syndrome; Lethal osteosclerotic bone dysplasia
GWAS		Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)	Allergic rhinitis ( 25085501) Alzheimer's disease in APOE e4- carriers ( 25778476)
Interacting Genes		54 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235	7 interacting genes: FAM118B PFDN1 SMN1 SUV39H2 TAF1D TK1 TSC22D1
Entrez ID		5201	56975
HPRD ID		05357	13298
Ensembl ID		ENSG00000113068	ENSG00000177706
Uniprot IDs		O60925	Q8IXL6
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD	5YH3
Enriched GO Terms of Interacting Partners?
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