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MEN1 and VIM
Data Source:
HPRD
(in vivo, in vitro)
MEN1
VIM
Description
menin 1
vimentin
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Lumen
Cytosol
Nuclear Matrix
Cleavage Furrow
Protein-containing Complex
Histone Methyltransferase Complex
Cytoplasm
Peroxisome
Cytosol
Polysome
Cytoskeleton
Intermediate Filament
Plasma Membrane
Focal Adhesion
Nuclear Matrix
Cell Leading Edge
Neuron Projection
Intermediate Filament Cytoskeleton
Phagocytic Vesicle
Extracellular Exosome
Ribonucleoprotein Complex
Molecular Function
Four-way Junction DNA Binding
Y-form DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Protein Binding
Histone-lysine N-methyltransferase Activity
Protein-macromolecule Adaptor Activity
Protein N-terminus Binding
R-SMAD Binding
Double-stranded RNA Binding
Structural Constituent Of Cytoskeleton
Structural Constituent Of Eye Lens
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Scaffold Protein Binding
Keratin Filament Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Negative Regulation Of Protein Phosphorylation
Osteoblast Development
DNA Repair
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Cell Population Proliferation
Response To UV
Response To Gamma Radiation
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Protein Binding
Histone Lysine Methylation
Negative Regulation Of DNA-binding Transcription Factor Activity
Post-translational Protein Modification
Cellular Protein Metabolic Process
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Negative Regulation Of Telomerase Activity
Beta-catenin-TCF Complex Assembly
Negative Regulation Of Neuron Projection Development
Astrocyte Development
Viral Process
Cytokine-mediated Signaling Pathway
Muscle Filament Sliding
Positive Regulation Of Collagen Biosynthetic Process
Regulation Of MRNA Stability
Intermediate Filament Organization
Positive Regulation Of Translation
Bergmann Glial Cell Differentiation
SMAD Protein Signal Transduction
Lens Fiber Cell Development
Cellular Response To Lipopolysaccharide
Cellular Response To Muramyl Dipeptide
Cellular Response To Interferon-gamma
Pathways
Formation of the beta-catenin:TCF transactivating complex
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Deactivation of the beta-catenin transactivating complex
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RHO GTPases activate IQGAPs
Post-translational protein phosphorylation
Caspase-mediated cleavage of cytoskeletal proteins
Striated Muscle Contraction
Interleukin-4 and Interleukin-13 signaling
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Drugs
Artenimol
Phenethyl Isothiocyanate
Diseases
Carcinoid
Adrenal carcinoma
Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
Malignant islet cell carcinoma
GWAS
Urate levels (
21768215
)
Cholesterol, total (
24097068
)
HDL cholesterol levels (
32203549
)
Mean spheric corpuscular volume (
32888494
)
Total cholesterol levels (
28334899
)
Triglyceride levels (
32203549
)
Interacting Genes
32 interacting genes:
ASH2L
CTNNB1
DAXX
DBF4
ESR1
FANCD2
FOXN3
GFAP
H3-4
HDAC1
HDAC2
IQGAP1
JUND
KMT2A
KMT2D
MYC
MYH9
NFKB1
NFKB2
POLR2B
RBBP5
RELA
RPA2
SIN3A
SMAD1
SMAD3
SMAD5
SNW1
TCF3
TCF7L2
TP53
VIM
171 interacting genes:
ABLIM1
AKT1
ANKRD35
ANXA7
APIP
APLP1
APP
ARMC7
ARMCX2
ATN1
BFSP1
BHLHE40
BRD1
BYSL
C2CD6
CAMK2D
CAPN1
CASP3
CASP6
CASP7
CASP8
CASP9
CBX8
CCDC187
CDH5
CDK1
CDKN1A
CEP126
CHD3
COPS6
CRCT1
CREB1
CRMP1
CT55
CWF19L2
DCTN1
DEFB1
DES
DIS3L2
DNM1L
DPPA4
DSP
DUX4
DYNLL1
ENTR1
ESS2
FABP4
FAM107A
FAM118B
FAM161A
FUBP1
GADD45A
GEM
GFAP
GOPC
GRB2
GSK3B
HABP4
HAP1
HMG20B
HSPB1
HTRA2
ING5
IP6K1
ITGB4
IVNS1ABP
KARS1
KAT7
KIAA0408
KIF15
KIF9
KIFC3
KRT20
KRT75
LGALS14
LINC01554
LORICRIN
LRIF1
MAFG
MAN2A2
MCPH1
MEN1
MICAL1
MRPL44
MTDH
NEFL
NEFM
NFATC2
NFKBID
NIF3L1
NME2
NOC4L
NR1H2
NUP85
OSBP2
PAK2
PDLIM1
PIAS4
PKD1
PKN1
PKP1
PLA2G2A
PLA2G4A
PLEC
PNMA5
POLR1C
PPHLN1
PPL
PPP1R18
PRKACA
PRPH
PSMA1
PSMC5
PSMD7
PSME1
PUF60
RAB8B
RABAC1
RAD51
RBM48
RIBC2
ROCK1
RPA1
SCNM1
SERBP1
SETDB1
SH3GL1
SH3GL3
SH3YL1
SIRPA
SIRT6
SLC25A6
SLC27A6
SMAD3
SMARCB1
SRRT
STK19
STX1A
SUMO2
SUMO3
SYN1
TAB2
TCEA2
TCHP
TLE5
TNFRSF14
TNNT1
TRIM14
TRIM15
TRIM28
TRIM29
TRIOBP
TSC22D1
TTR
TUBA1C
TUBGCP4
TXLNB
TXN
TXN2
UPP1
UPP2
UROD
UTP14A
WBP11
XRCC4
YAE1
YWHAE
YWHAZ
ZHX1
ZNF384
ZNF572
Entrez ID
4221
7431
HPRD ID
00564
01899
Ensembl ID
ENSG00000133895
ENSG00000026025
Uniprot IDs
A0A024R5D2
A0A024R5E3
A0A5F9ZHS3
O00255
Q9GZQ5
P08670
V9HWE1
PDB IDs
3U84
3U85
3U86
3U88
4GPQ
4GQ3
4GQ4
4GQ6
4I80
4OG3
4OG4
4OG5
4OG6
4OG7
4OG8
4X5Y
4X5Z
5DB0
5DB1
5DB2
5DB3
5DD9
5DDA
5DDB
5DDC
5DDD
5DDE
5DDF
6B41
6BXH
6BXY
6BY8
6E1A
6O5I
6OPJ
6PKC
6WNH
1GK4
1GK6
1GK7
3G1E
3KLT
3S4R
3SSU
3SWK
3TRT
3UF1
4MCY
4MCZ
4MD0
4MD5
4MDI
4MDJ
4YPC
4YV3
5WHF
6ATF
6ATI
6BIR
Enriched GO Terms of Interacting Partners
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