VIM and PLA2G2A

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		VIM	PLA2G2A
Description		vimentin	phospholipase A2 group IIA
Image
GO Annotations	Cellular Component	Cytoplasm Peroxisome Cytosol Polysome Cytoskeleton Intermediate Filament Plasma Membrane Focal Adhesion Nuclear Matrix Cell Leading Edge Neuron Projection Intermediate Filament Cytoskeleton Phagocytic Vesicle Extracellular Exosome Ribonucleoprotein Complex	Extracellular Region Extracellular Space Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Secretory Granule Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Double-stranded RNA Binding Structural Constituent Of Cytoskeleton Structural Constituent Of Eye Lens Protein Binding Protein Domain Specific Binding Identical Protein Binding Scaffold Protein Binding Keratin Filament Binding	Phospholipase A2 Activity Calcium Ion Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
	Biological Process	Negative Regulation Of Neuron Projection Development Astrocyte Development Viral Process Cytokine-mediated Signaling Pathway Muscle Filament Sliding Positive Regulation Of Collagen Biosynthetic Process Regulation Of MRNA Stability Intermediate Filament Organization Positive Regulation Of Translation Bergmann Glial Cell Differentiation SMAD Protein Signal Transduction Lens Fiber Cell Development Cellular Response To Lipopolysaccharide Cellular Response To Muramyl Dipeptide Cellular Response To Interferon-gamma	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Inflammatory Response Positive Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Catabolic Process Antimicrobial Humoral Response Cytolysis Low-density Lipoprotein Particle Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Intestinal Stem Cell Homeostasis Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidic Acid Metabolic Process Arachidonic Acid Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Neutrophil Activation
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Striated Muscle Contraction Interleukin-4 and Interleukin-13 signaling Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA Antimicrobial peptides
Drugs		Artenimol Phenethyl Isothiocyanate	Indomethacin Ginkgo biloba 1,4-Butanediol 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene N-Tridecanoic Acid [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid Lauric acid (1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 6-phenyl-4(R)-(7-phenyl-heptanoylamino)-hexanoic acid Elaidamide (2R)-2-Acetamido-3-(octadecyloxy)propyl 2-(methylsulfanyl)ethyl hydrogen phosphate KH064 Suramin Varespladib methyl
Diseases
GWAS		Cholesterol, total ( 24097068) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494) Total cholesterol levels ( 28334899) Triglyceride levels ( 32203549)	Blood protein levels ( 30072576 29875488) group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Immunoglobulin light chain (AL) amyloidosis ( 28025584)
Interacting Genes		171 interacting genes: ABLIM1 AKT1 ANKRD35 ANXA7 APIP APLP1 APP ARMC7 ARMCX2 ATN1 BFSP1 BHLHE40 BRD1 BYSL C2CD6 CAMK2D CAPN1 CASP3 CASP6 CASP7 CASP8 CASP9 CBX8 CCDC187 CDH5 CDK1 CDKN1A CEP126 CHD3 COPS6 CRCT1 CREB1 CRMP1 CT55 CWF19L2 DCTN1 DEFB1 DES DIS3L2 DNM1L DPPA4 DSP DUX4 DYNLL1 ENTR1 ESS2 FABP4 FAM107A FAM118B FAM161A FUBP1 GADD45A GEM GFAP GOPC GRB2 GSK3B HABP4 HAP1 HMG20B HSPB1 HTRA2 ING5 IP6K1 ITGB4 IVNS1ABP KARS1 KAT7 KIAA0408 KIF15 KIF9 KIFC3 KRT20 KRT75 LGALS14 LINC01554 LORICRIN LRIF1 MAFG MAN2A2 MCPH1 MEN1 MICAL1 MRPL44 MTDH NEFL NEFM NFATC2 NFKBID NIF3L1 NME2 NOC4L NR1H2 NUP85 OSBP2 PAK2 PDLIM1 PIAS4 PKD1 PKN1 PKP1 PLA2G2A PLA2G4A PLEC PNMA5 POLR1C PPHLN1 PPL PPP1R18 PRKACA PRPH PSMA1 PSMC5 PSMD7 PSME1 PUF60 RAB8B RABAC1 RAD51 RBM48 RIBC2 ROCK1 RPA1 SCNM1 SERBP1 SETDB1 SH3GL1 SH3GL3 SH3YL1 SIRPA SIRT6 SLC25A6 SLC27A6 SMAD3 SMARCB1 SRRT STK19 STX1A SUMO2 SUMO3 SYN1 TAB2 TCEA2 TCHP TLE5 TNFRSF14 TNNT1 TRIM14 TRIM15 TRIM28 TRIM29 TRIOBP TSC22D1 TTR TUBA1C TUBGCP4 TXLNB TXN TXN2 UPP1 UPP2 UROD UTP14A WBP11 XRCC4 YAE1 YWHAE YWHAZ ZHX1 ZNF384 ZNF572	26 interacting genes: ALOX12 BAG6 CEP70 CRMP1 DCN ITGAV ITGB3 JOSD2 PLA2G1B PLA2R1 SENP6 SENP8 UCHL1 UCHL3 UCHL5 USP15 USP2 USP20 USP28 USP4 USP47 USP5 USP7 USP8 VCAN VIM
Entrez ID		7431	5320
HPRD ID		01899	01397
Ensembl ID		ENSG00000026025	ENSG00000188257
Uniprot IDs		P08670 V9HWE1	A0A024RA96 P14555
PDB IDs		1GK4 1GK6 1GK7 3G1E 3KLT 3S4R 3SSU 3SWK 3TRT 3UF1 4MCY 4MCZ 4MD0 4MD5 4MDI 4MDJ 4YPC 4YV3 5WHF 6ATF 6ATI 6BIR	1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 2GNY 3U8B 3U8D 3U8H 3U8I 5G3N
Enriched GO Terms of Interacting Partners?
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