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VIM and TNFRSF14
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
VIM
TNFRSF14
Description
vimentin
TNF receptor superfamily member 14
Image
GO Annotations
Cellular Component
Cytoplasm
Peroxisome
Cytosol
Polysome
Cytoskeleton
Intermediate Filament
Plasma Membrane
Focal Adhesion
Nuclear Matrix
Cell Leading Edge
Neuron Projection
Intermediate Filament Cytoskeleton
Phagocytic Vesicle
Extracellular Exosome
Ribonucleoprotein Complex
Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
Molecular Function
Double-stranded RNA Binding
Structural Constituent Of Cytoskeleton
Structural Constituent Of Eye Lens
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Scaffold Protein Binding
Keratin Filament Binding
Virus Receptor Activity
Tumor Necrosis Factor-activated Receptor Activity
Protein Binding
Cytokine Binding
Ubiquitin Protein Ligase Binding
Biological Process
Negative Regulation Of Neuron Projection Development
Astrocyte Development
Viral Process
Cytokine-mediated Signaling Pathway
Muscle Filament Sliding
Positive Regulation Of Collagen Biosynthetic Process
Regulation Of MRNA Stability
Intermediate Filament Organization
Positive Regulation Of Translation
Bergmann Glial Cell Differentiation
SMAD Protein Signal Transduction
Lens Fiber Cell Development
Cellular Response To Lipopolysaccharide
Cellular Response To Muramyl Dipeptide
Cellular Response To Interferon-gamma
Adaptive Immune Response
Positive Regulation Of Cytokine Production Involved In Immune Response
Immune Response
Cell Surface Receptor Signaling Pathway
T Cell Costimulation
Tumor Necrosis Factor-mediated Signaling Pathway
Innate Immune Response
Negative Regulation Of Alpha-beta T Cell Proliferation
Viral Entry Into Host Cell
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Gram-negative Bacterium
Defense Response To Gram-positive Bacterium
Negative Regulation Of Adaptive Immune Memory Response
Positive Regulation Of T Cell Migration
Pathways
Caspase-mediated cleavage of cytoskeletal proteins
Striated Muscle Contraction
Interleukin-4 and Interleukin-13 signaling
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Costimulation by the CD28 family
Costimulation by the CD28 family
TNFs bind their physiological receptors
Drugs
Artenimol
Phenethyl Isothiocyanate
Diseases
GWAS
Cholesterol, total (
24097068
)
HDL cholesterol levels (
32203549
)
Mean spheric corpuscular volume (
32888494
)
Total cholesterol levels (
28334899
)
Triglyceride levels (
32203549
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Autoimmune thyroid disease (
32581359
)
Body mass index (
26426971
)
Celiac disease (
20190752
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Inflammatory bowel disease (
28067908
)
Medication use (thyroid preparations) (
31015401
)
Multiple sclerosis (
28445677
)
Primary sclerosing cholangitis (
23603763
)
Rheumatoid arthritis (
24449572
30423114
18794853
24390342
20453842
)
Ulcerative colitis (
28067908
26398853
23128233
21297633
)
Interacting Genes
171 interacting genes:
ABLIM1
AKT1
ANKRD35
ANXA7
APIP
APLP1
APP
ARMC7
ARMCX2
ATN1
BFSP1
BHLHE40
BRD1
BYSL
C2CD6
CAMK2D
CAPN1
CASP3
CASP6
CASP7
CASP8
CASP9
CBX8
CCDC187
CDH5
CDK1
CDKN1A
CEP126
CHD3
COPS6
CRCT1
CREB1
CRMP1
CT55
CWF19L2
DCTN1
DEFB1
DES
DIS3L2
DNM1L
DPPA4
DSP
DUX4
DYNLL1
ENTR1
ESS2
FABP4
FAM107A
FAM118B
FAM161A
FUBP1
GADD45A
GEM
GFAP
GOPC
GRB2
GSK3B
HABP4
HAP1
HMG20B
HSPB1
HTRA2
ING5
IP6K1
ITGB4
IVNS1ABP
KARS1
KAT7
KIAA0408
KIF15
KIF9
KIFC3
KRT20
KRT75
LGALS14
LINC01554
LORICRIN
LRIF1
MAFG
MAN2A2
MCPH1
MEN1
MICAL1
MRPL44
MTDH
NEFL
NEFM
NFATC2
NFKBID
NIF3L1
NME2
NOC4L
NR1H2
NUP85
OSBP2
PAK2
PDLIM1
PIAS4
PKD1
PKN1
PKP1
PLA2G2A
PLA2G4A
PLEC
PNMA5
POLR1C
PPHLN1
PPL
PPP1R18
PRKACA
PRPH
PSMA1
PSMC5
PSMD7
PSME1
PUF60
RAB8B
RABAC1
RAD51
RBM48
RIBC2
ROCK1
RPA1
SCNM1
SERBP1
SETDB1
SH3GL1
SH3GL3
SH3YL1
SIRPA
SIRT6
SLC25A6
SLC27A6
SMAD3
SMARCB1
SRRT
STK19
STX1A
SUMO2
SUMO3
SYN1
TAB2
TCEA2
TCHP
TLE5
TNFRSF14
TNNT1
TRIM14
TRIM15
TRIM28
TRIM29
TRIOBP
TSC22D1
TTR
TUBA1C
TUBGCP4
TXLNB
TXN
TXN2
UPP1
UPP2
UROD
UTP14A
WBP11
XRCC4
YAE1
YWHAE
YWHAZ
ZHX1
ZNF384
ZNF572
30 interacting genes:
A2M
APP
BTLA
CD160
CEP126
CHD3
DGKD
DRAP1
DYNLL1
ESR1
HDAC3
HDAC4
IMPA2
ITFG1
LTA
MBTPS1
NDUFS2
NRIP1
RAD21
SERPINA4
TNFSF13
TNFSF14
TRAF1
TRAF2
TRAF3
TRAF5
UBQLN4
VIM
WDR73
ZBTB48
Entrez ID
7431
8764
HPRD ID
01899
04122
Ensembl ID
ENSG00000026025
ENSG00000157873
Uniprot IDs
P08670
V9HWE1
A0A024R052
Q92956
PDB IDs
1GK4
1GK6
1GK7
3G1E
3KLT
3S4R
3SSU
3SWK
3TRT
3UF1
4MCY
4MCZ
4MD0
4MD5
4MDI
4MDJ
4YPC
4YV3
5WHF
6ATF
6ATI
6BIR
1JMA
2AW2
4FHQ
4RSU
5T2Q
5T2R
6NG3
Enriched GO Terms of Interacting Partners
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