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MEN1 and GFAP
Data Source:
BioGRID
(pull down)
HPRD
(in vitro, in vivo)
MEN1
GFAP
Description
menin 1
glial fibrillary acidic protein
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum Lumen
Cytosol
Nuclear Matrix
Cleavage Furrow
Protein-containing Complex
Histone Methyltransferase Complex
Cytoplasm
Lysosome
Cytosol
Intermediate Filament
Intermediate Filament Cytoskeleton
Molecular Function
Four-way Junction DNA Binding
Y-form DNA Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Protein Binding
Histone-lysine N-methyltransferase Activity
Protein-macromolecule Adaptor Activity
Protein N-terminus Binding
R-SMAD Binding
Structural Constituent Of Cytoskeleton
Protein Binding
Identical Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Negative Regulation Of Protein Phosphorylation
Osteoblast Development
DNA Repair
Regulation Of Transcription By RNA Polymerase II
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Cell Population Proliferation
Response To UV
Response To Gamma Radiation
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Protein Binding
Histone Lysine Methylation
Negative Regulation Of DNA-binding Transcription Factor Activity
Post-translational Protein Modification
Cellular Protein Metabolic Process
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of JNK Cascade
Negative Regulation Of Telomerase Activity
Beta-catenin-TCF Complex Assembly
Regulation Of Protein-containing Complex Assembly
Intermediate Filament Organization
Regulation Of Chaperone-mediated Autophagy
Pathways
Formation of the beta-catenin:TCF transactivating complex
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Deactivation of the beta-catenin transactivating complex
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RHO GTPases activate IQGAPs
Post-translational protein phosphorylation
Nuclear signaling by ERBB4
Chaperone Mediated Autophagy
Drugs
Diseases
Carcinoid
Adrenal carcinoma
Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
Malignant islet cell carcinoma
Alexander disease
GWAS
Urate levels (
21768215
)
Asthma (
31619474
)
Cognitive function (
25644384
)
Craniofacial microsomia (
26853712
)
Interacting Genes
32 interacting genes:
ASH2L
CTNNB1
DAXX
DBF4
ESR1
FANCD2
FOXN3
GFAP
H3-4
HDAC1
HDAC2
IQGAP1
JUND
KMT2A
KMT2D
MYC
MYH9
NFKB1
NFKB2
POLR2B
RBBP5
RELA
RPA2
SIN3A
SMAD1
SMAD3
SMAD5
SNW1
TCF3
TCF7L2
TP53
VIM
80 interacting genes:
ABI2
AKT1
APP
AURKB
BIRC2
CAMK2A
CARD10
CCDC57
CDC37
CDK1
CEP76
CFAP206
CRYAB
CT55
CWF19L2
DES
ENKD1
EPM2AIP1
FAM50B
GOLGA2
GRAP2
HGS
HOMEZ
IKBKG
KIAA0408
KRT13
KRT15
KRT19
KRT27
KRT31
KRT39
LENG1
LGALS14
LMO2
MAPK9
MEN1
MOS
MYBPHL
MYO15B
NEFL
NEK6
NFKBID
NTAQ1
NXF1
PDLIM1
PDLIM7
PDZK1
PIAS2
PIH1D2
POM121
PPP1R16B
PPP1R18
PRKACA
PRKCA
PRKCG
PSEN1
PSEN2
RIBC2
ROCK1
RORA
S100A1
S100B
SH3YL1
SMARCB1
SRC
STAT1
TBC1D21
TBC1D22B
TFIP11
TLE5
TP53BP2
TRIM27
TUBGCP4
UBASH3A
UBE3A
VIM
YES1
ZC2HC1C
ZNF655
ZNF774
Entrez ID
4221
2670
HPRD ID
00564
00675
Ensembl ID
ENSG00000133895
ENSG00000131095
Uniprot IDs
A0A024R5D2
A0A024R5E3
A0A5F9ZHS3
O00255
Q9GZQ5
A7REI1
P14136
PDB IDs
3U84
3U85
3U86
3U88
4GPQ
4GQ3
4GQ4
4GQ6
4I80
4OG3
4OG4
4OG5
4OG6
4OG7
4OG8
4X5Y
4X5Z
5DB0
5DB1
5DB2
5DB3
5DD9
5DDA
5DDB
5DDC
5DDD
5DDE
5DDF
6B41
6BXH
6BXY
6BY8
6E1A
6O5I
6OPJ
6PKC
6WNH
6A9P
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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