IFIT3 and ECSIT

Data Source:
BioGRID (two hybrid)

		IFIT3	ECSIT
Description		interferon induced protein with tetratricopeptide repeats 3	ECSIT signaling integrator
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol
	Molecular Function	Molecular_function RNA Binding Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation Response To Virus Cellular Response To Interferon-alpha Negative Regulation Of Apoptotic Process Defense Response To Virus Type I Interferon Signaling Pathway	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability
Pathways		Interferon alpha/beta signaling	MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Hormone measurements ( 30576415)	Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		20 interacting genes: A2M APOE CYP2C8 DEUP1 ECSIT FANCA HAUS1 IFIT1 IFIT1B IFIT2 IFIT5 LONP1 LVRN MAST1 PSEN2 RAD23A RNF32 TMEM183A TPM1 TPM3	52 interacting genes: A2M AP1M2 APOE APP BFSP2 BLMH C1orf109 CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3
Entrez ID		3437	51295
HPRD ID		05228	12225
Ensembl ID		ENSG00000119917	ENSG00000130159
Uniprot IDs		O14879 Q5T765	Q9BQ95
PDB IDs		6C6K
Enriched GO Terms of Interacting Partners?
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