ECSIT and PI4K2A

Data Source:
BioGRID (two hybrid)

		ECSIT	PI4K2A
Description		ECSIT signaling integrator	phosphatidylinositol 4-kinase type 2 alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol	Mitochondrion Lysosomal Membrane Endosome Trans-Golgi Network Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite BLOC-1 Complex Intrinsic Component Of Membrane Cytoplasmic Vesicle Growing Cell Tip Presynaptic Membrane Neuron Projection Neuronal Cell Body Perikaryon Membrane Raft
	Molecular Function	Protein Binding	Magnesium Ion Binding 1-phosphatidylinositol 4-kinase Activity Protein Binding ATP Binding AP-3 Adaptor Complex Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Phosphatidylinositol Biosynthetic Process Golgi Organization Endosome Organization Phosphatidylinositol Phosphorylation
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane	Synthesis of PIPs at the plasma membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane
Drugs
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		52 interacting genes: A2M AP1M2 APOE APP BFSP2 BLMH C1orf109 CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3	6 interacting genes: APP CD63 ECSIT HRAS NOS3 RAD23A
Entrez ID		51295	55361
HPRD ID		12225	11431
Ensembl ID		ENSG00000130159	ENSG00000155252
Uniprot IDs		Q9BQ95	Q9BTU6
PDB IDs			4HND 4HNE 4PLA 4YC4 5EUT 5I0N
Enriched GO Terms of Interacting Partners?
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