ECSIT and TARS3

		ECSIT	TARS3
Description		ECSIT signaling integrator	threonyl-tRNA synthetase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Cytosol	Cellular_component Nucleus Cytoplasm
	Molecular Function	Protein Binding	Molecular_function Threonine-tRNA Ligase Activity Protein Binding ATP Binding
	Biological Process	Mitochondrial Respiratory Chain Complex I Assembly Innate Immune Response Regulation Of Oxidoreductase Activity Regulation Of Protein Complex Stability	Threonyl-tRNA Aminoacylation Biological_process
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane Complex I biogenesis TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Presence of antiphospholipid antibodies ( 27098658)
Interacting Genes		52 interacting genes: A2M AP1M2 APOE APP BFSP2 BLMH C1orf109 CDC37 CEP55 CTNNA3 CYP2C18 CYP2C8 CYP2C9 DNAJB1 DTX2 ELAVL3 EXOC6 EXOSC1 FARSA FBXL12 FBXW4 GCDH GEM IFIT3 IFIT5 IMMT LONP1 LOXL4 MAGEB2 MAST1 MKRN3 NFKB1 NXF1 PAXIP1 PI4K2A PRDX2 PSEN1 RAB3A RAD23A RELA RHEB RNF32 SETDB1 SMAD1 SMAD4 SMURF1 STAMBPL1 STRN4 TARS3 TRAF6 TRIM59 TSSK3	6 interacting genes: ARPC3 ATF4 ECSIT LGALS14 TARS1 TARS2
Entrez ID		51295	123283
HPRD ID		12225	15469
Ensembl ID		ENSG00000130159	ENSG00000185418
Uniprot IDs		Q9BQ95	A2RTX5
PDB IDs
Enriched GO Terms of Interacting Partners?
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