EPN1 and TFAP2A

Data Source:
BioGRID (pull down, affinity chromatography technology)

		EPN1	TFAP2A
Description		epsin 1	transcription factor AP-2 alpha
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endosome Cytosol Plasma Membrane Clathrin-coated Pit Clathrin Vesicle Coat Intracellular Membrane-bounded Organelle	Chromatin Nucleus Nucleoplasm
	Molecular Function	Protein Binding Phospholipid Binding Clathrin Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization Negative Regulation Of Sprouting Angiogenesis	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Optic Vesicle Morphogenesis Optic Cup Structural Organization Regulation Of Transcription By RNA Polymerase II Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Retina Layer Formation Negative Regulation Of Transcription By Competitive Promoter Binding Trigeminal Nerve Development Oculomotor Nerve Formation Positive Regulation Of Bone Mineralization Embryonic Forelimb Morphogenesis Regulation Of Cell Population Proliferation Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Anatomical Structure Development Roof Of Mouth Development Bone Morphogenesis Eyelid Development In Camera-type Eye Positive Regulation Of Tooth Mineralization Cellular Response To Iron Ion Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2 (AP-2) family regulates transcription of cell cycle factors TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs		1,4-Dioxane 1D-myo-inositol 1,4,5-trisphosphate
Diseases			Branchiooculofacial syndrome (BOFS)
GWAS		Major depressive disorder ( 23377640)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Breast cancer in BRCA2 mutation carriers ( 23544012) Glucose homeostasis traits ( 25524916) Iron status biomarkers (ferritin levels) ( 28334935) Metabolite levels ( 23823483) Ovarian cancer ( 30557369) Refractive error ( 32231278) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Zinc levels ( 26025379)
Interacting Genes		25 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 LITAF MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A UBC ZBTB16	38 interacting genes: APC CASP1 CASP3 CASP6 CITED2 CITED4 CLTC CSNK2A1 CSNK2B CTNNB1 DEK EP300 EPN1 EPN2 EPS15 GSTO2 HIP1 INCA1 KCTD15 LDLRAP1 MAGI1 MKRN3 MYC NFKB1 NPM1 PPARG PRKAA2 PRKD1 RB1 SRA1 SUMO4 SYT1 TP53 UBE2I VEGFA WWP1 WWP2 YBX1
Entrez ID		29924	7020
HPRD ID		06270	00128
Ensembl ID		ENSG00000063245	ENSG00000137203
Uniprot IDs		A0A024R4S1 Q9Y6I3	P05549
PDB IDs		1INZ 1KYD
Enriched GO Terms of Interacting Partners?
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