EPN1 and PLEKHB2

Data Source:
BioGRID (two hybrid)

		EPN1	PLEKHB2
Description		epsin 1	pleckstrin homology domain containing B2
Image
GO Annotations	Cellular Component	Nucleus Endosome Cytosol Plasma Membrane Clathrin-coated Pit Clathrin Vesicle Coat Intracellular Membrane-bounded Organelle	Integral Component Of Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding Phospholipid Binding Clathrin Binding	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding
	Biological Process	Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization Negative Regulation Of Sprouting Angiogenesis	Regulation Of Cell Differentiation
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		1,4-Dioxane 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Major depressive disorder ( 23377640)
Interacting Genes		25 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 LITAF MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A UBC ZBTB16	49 interacting genes: ATF7IP BHLHE40 C1orf94 CD68 CDA CLDN19 DAZAP2 DCUN1D1 EMP1 EMP3 EPN1 EPN2 FAM168A FOXD4L3 GGA3 GJB2 GLIS2 HEY1 HEYL HGS HIVEP1 MAP3K1 MED25 MTURN NTAQ1 OTUB2 PIP4P1 PITX1 POGZ PROP1 RHBDD1 RPS27A SFT2D1 SNRPB STAM2 SYNGR1 TAX1BP1 TRARG1 UBA52 UBAC1 UBAP2 UBASH3A UBB UBC UBQLN2 UBXN6 UPF1 YOD1 ZFAND2A
Entrez ID		29924	55041
HPRD ID		06270	15144
Ensembl ID		ENSG00000063245	ENSG00000115762
Uniprot IDs		A0A024R4S1 Q9Y6I3	A0A024QZ35 A0A0A0MSE9 A0A0A0MSI4 B4DJB7 Q96CS7
PDB IDs		1INZ 1KYD	3AJ4 3VIA
Enriched GO Terms of Interacting Partners?
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