EPN1 and CRMP1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EPN1	CRMP1
Description		epsin 1	collapsin response mediator protein 1
Image
GO Annotations	Cellular Component	Nucleus Endosome Cytosol Plasma Membrane Clathrin-coated Pit Clathrin Vesicle Coat Intracellular Membrane-bounded Organelle	Nucleus Centrosome Spindle Cytosol Growth Cone Midbody Perikaryon
	Molecular Function	Protein Binding Phospholipid Binding Clathrin Binding	Dihydropyrimidinase Activity Protein Binding Filamin Binding Identical Protein Binding
	Biological Process	Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization Negative Regulation Of Sprouting Angiogenesis	Microtubule Cytoskeleton Organization Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Catabolic Process Nervous System Development Axon Guidance Negative Regulation Of Neuron Projection Development Negative Regulation Of Actin Filament Binding
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	CRMPs in Sema3A signaling
Drugs		1,4-Dioxane 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Major depressive disorder ( 23377640)	Blood trace element (Zn levels) ( 23720494) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		25 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 LITAF MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A UBC ZBTB16	80 interacting genes: AGR2 ALDH2 AMFR ANXA7 AP3M1 ARL15 AXIN1 BID BTBD2 CACNA1A CCDC106 CCL18 CCT7 CDK5RAP2 CDK5RAP3 DDX18 DNAJB11 DPYSL2 DPYSL3 DUSP4 EEF1D EIF2S2 EPN1 EXOSC8 FAS FTH1 FUBP1 FXR1 GNE GOLGA2 HDHD2 HGS HMGB1 HNRNPH1 HNRNPH3 HNRNPUL1 HSPE1 HTT IL33 KLHL20 LRRC1 LRRK2 LSM2 MAP3K20 MAPK8IP2 MCM3AP MOB4 MRPS12 NAT9 NDUFV2 NVL PAFAH1B3 PFN1 PLA2G2A PMF1 PPP1R8 PSMD11 RACK1 RGL2 RGS2 ROCK1 RPA2 RPS6KA5 RTN4 SAT1 SEPHS1 SERPINB9 SNRPG SPRY2 SRC TFG TK1 TRIP13 TSC22D1 UBE2A UBE2B VCP VIM YAE1 ZNF24
Entrez ID		29924	1400
HPRD ID		06270	03913
Ensembl ID		ENSG00000063245	ENSG00000072832
Uniprot IDs		A0A024R4S1 Q9Y6I3	B3KT07 B3KV96 E9PD68 Q14194 Q96I11 X5DNI1
PDB IDs		1INZ 1KYD	4B3Z
Enriched GO Terms of Interacting Partners?
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