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TFAP2A and WWP1
Data Source:
HPRD
(in vitro)
TFAP2A
WWP1
Description
transcription factor AP-2 alpha
WW domain containing E3 ubiquitin protein ligase 1
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Ubiquitin Ligase Complex
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Extracellular Exosome
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
Protein Binding
Identical Protein Binding
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Ubiquitin Protein Ligase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Kidney Development
Optic Vesicle Morphogenesis
Optic Cup Structural Organization
Regulation Of Transcription By RNA Polymerase II
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Retina Layer Formation
Negative Regulation Of Transcription By Competitive Promoter Binding
Trigeminal Nerve Development
Oculomotor Nerve Formation
Positive Regulation Of Bone Mineralization
Embryonic Forelimb Morphogenesis
Regulation Of Cell Population Proliferation
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Embryonic Cranial Skeleton Morphogenesis
Anatomical Structure Development
Roof Of Mouth Development
Bone Morphogenesis
Eyelid Development In Camera-type Eye
Positive Regulation Of Tooth Mineralization
Cellular Response To Iron Ion
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Protein Polyubiquitination
Signal Transduction
Central Nervous System Development
Protein Ubiquitination
Ion Transmembrane Transport
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Transcription, DNA-templated
Viral Entry Into Host Cell
Pathways
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
TFAP2 (AP-2) family regulates transcription of other transcription factors
Activation of the TFAP2 (AP-2) family of transcription factors
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
TFAP2 (AP-2) family regulates transcription of cell cycle factors
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Downregulation of ERBB4 signaling
Stimuli-sensing channels
Regulation of RUNX2 expression and activity
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Branchiooculofacial syndrome (BOFS)
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Breast cancer in BRCA2 mutation carriers (
23544012
)
Glucose homeostasis traits (
25524916
)
Iron status biomarkers (ferritin levels) (
28334935
)
Metabolite levels (
23823483
)
Ovarian cancer (
30557369
)
Refractive error (
32231278
)
Response to (pegylated) interferon in HBeAg-negative hepatitis B (
30715261
)
Zinc levels (
26025379
)
Estimated glomerular filtration rate (
31152163
)
Interacting Genes
38 interacting genes:
APC
CASP1
CASP3
CASP6
CITED2
CITED4
CLTC
CSNK2A1
CSNK2B
CTNNB1
DEK
EP300
EPN1
EPN2
EPS15
GSTO2
HIP1
INCA1
KCTD15
LDLRAP1
MAGI1
MKRN3
MYC
NFKB1
NPM1
PPARG
PRKAA2
PRKD1
RB1
SRA1
SUMO4
SYT1
TP53
UBE2I
VEGFA
WWP1
WWP2
YBX1
55 interacting genes:
ARRDC1
ARRDC2
ARRDC3
ASH2L
ATN1
CLCN5
CPSF6
DAG1
DAZAP2
DIDO1
EWSR1
FAM189A2
FBXL18
HSPB1
IKBKG
IL2RG
IL6R
KLF2
KLF5
LAPTM5
LATS1
LNX1
LZTR1
MACROH2A2
MIR19A
MIR19B1
NFE2
NOTCH1
PCBD1
PHF20L1
PRKAA2
PYGM
RASA1
RNF11
RTN4
RUNX1
SCNN1A
SFTPC
SMAD3
SMAD5
STAT6
TFAP2A
TGIF1
TP53BP2
TRAF4
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2L3
WASL
WBP1
WBP2
YWHAQ
ZNF638
Entrez ID
7020
11059
HPRD ID
00128
03811
Ensembl ID
ENSG00000137203
ENSG00000123124
Uniprot IDs
P05549
Q9H0M0
PDB IDs
1ND7
2OP7
5HPS
5HPT
6J1X
6J1Y
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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