EPN1 and SCNN1G

Data Source:
BioGRID (pull down)

		EPN1	SCNN1G
Description		epsin 1	sodium channel epithelial 1 subunit gamma
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GO Annotations	Cellular Component	Nucleus Endosome Cytosol Plasma Membrane Clathrin-coated Pit Clathrin Vesicle Coat Intracellular Membrane-bounded Organelle	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Apical Plasma Membrane Sodium Channel Complex Extracellular Exosome Plasma Membrane Protein Complex
	Molecular Function	Protein Binding Phospholipid Binding Clathrin Binding	Ion Channel Activity Sodium Channel Activity Protein Binding Ligand-gated Sodium Channel Activity WW Domain Binding
	Biological Process	Endocytosis Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Membrane Organization Negative Regulation Of Sprouting Angiogenesis	Sodium Ion Transport Excretion Ion Transmembrane Transport Sodium Ion Transmembrane Transport Multicellular Organismal Water Homeostasis Sensory Perception Of Taste Sodium Ion Homeostasis Cellular Response To Aldosterone
Pathways		EGFR downregulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Stimuli-sensing channels
Drugs		1,4-Dioxane 1D-myo-inositol 1,4,5-trisphosphate	Triamterene Amiloride
Diseases			Liddle syndrome Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome) Bronchiectasis with or without elevated sweat chloride
GWAS		Major depressive disorder ( 23377640)	Heel bone mineral density ( 30598549) Parent of origin effect on receptive language ability (paternal) ( 32635940)
Interacting Genes		25 interacting genes: AP2A1 AP2A2 CDK1 CEP126 CLTC CRMP1 DAZAP2 EPS15 EPS15L1 FBXO25 HIP1R LAPTM5 LITAF MAP3K1 MED31 PLEKHB2 REPS2 RNF11 SCNN1A SCNN1B SCNN1G SMURF1 TFAP2A UBC ZBTB16	13 interacting genes: COMMD10 EPN1 MAPK1 NEDD4 NEDD4L SCNN1A SCNN1B SCNN1D SERP1 SOX4 STX1A USP10 WWP2
Entrez ID		29924	6340
HPRD ID		06270	02862
Ensembl ID		ENSG00000063245	ENSG00000166828
Uniprot IDs		A0A024R4S1 Q9Y6I3	A5X2V1 P51170
PDB IDs		1INZ 1KYD	6BQN 6WTH
Enriched GO Terms of Interacting Partners?
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