TFAP2A and YBX1

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		TFAP2A	YBX1
Description		transcription factor AP-2 alpha	Y-box binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Extracellular Region Nucleus Nucleoplasm U12-type Spliceosomal Complex Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome CRD-mediated MRNA Stability Complex Histone Pre-mRNA 3'end Processing Complex Messenger Ribonucleoprotein Complex Ribonucleoprotein Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding Identical Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Nucleic Acid Binding DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding MiRNA Binding GTPase Binding C5-methylcytidine-containing RNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Optic Vesicle Morphogenesis Optic Cup Structural Organization Regulation Of Transcription By RNA Polymerase II Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Retina Layer Formation Negative Regulation Of Transcription By Competitive Promoter Binding Trigeminal Nerve Development Oculomotor Nerve Formation Positive Regulation Of Bone Mineralization Embryonic Forelimb Morphogenesis Regulation Of Cell Population Proliferation Inner Ear Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Anatomical Structure Development Roof Of Mouth Development Bone Morphogenesis Eyelid Development In Camera-type Eye Positive Regulation Of Tooth Mineralization Cellular Response To Iron Ion Negative Regulation Of Reactive Oxygen Species Metabolic Process	MRNA Splicing, Via Spliceosome Regulation Of Transcription, DNA-templated Notch Signaling Pathway Epidermis Development Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Embryonic Morphogenesis RNA Transport TRNA Transport Positive Regulation Of Cell Division CRD-mediated MRNA Stabilization Protein Localization To Cytoplasmic Stress Granule MiRNA Transport Negative Regulation Of Cellular Senescence
Pathways		Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2 (AP-2) family regulates transcription of other transcription factors Activation of the TFAP2 (AP-2) family of transcription factors TFAP2 (AP-2) family regulates transcription of growth factors and their receptors TFAP2 (AP-2) family regulates transcription of cell cycle factors TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Noncanonical activation of NOTCH3
Drugs
Diseases		Branchiooculofacial syndrome (BOFS)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Breast cancer in BRCA2 mutation carriers ( 23544012) Glucose homeostasis traits ( 25524916) Iron status biomarkers (ferritin levels) ( 28334935) Metabolite levels ( 23823483) Ovarian cancer ( 30557369) Refractive error ( 32231278) Response to (pegylated) interferon in HBeAg-negative hepatitis B ( 30715261) Zinc levels ( 26025379)
Interacting Genes		38 interacting genes: APC CASP1 CASP3 CASP6 CITED2 CITED4 CLTC CSNK2A1 CSNK2B CTNNB1 DEK EP300 EPN1 EPN2 EPS15 GSTO2 HIP1 INCA1 KCTD15 LDLRAP1 MAGI1 MKRN3 MYC NFKB1 NPM1 PPARG PRKAA2 PRKD1 RB1 SRA1 SUMO4 SYT1 TP53 UBE2I VEGFA WWP1 WWP2 YBX1	116 interacting genes: ACTA2 AKT1 ANKRD2 APBB1 CALM1 CASP8 CSNK2A1 CTCF DUX4 FBXO33 FMR1 FUS GSK3B H1-2 HABP4 HLA-C HNRNPD HNRNPK IL7R IREB2 IRF1 JAM2 LCP2 LSM3 MAPK1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC MYCN NFYB PCBP2 PCNA PRPF40A PURA RBBP6 RPS6KA1 RPS6KA3 SLC6A4 SMAD3 SMU1 SREK1 SRSF9 TFAP2A TP53 TRAF6 VEGFA
Entrez ID		7020	4904
HPRD ID		00128	01095
Ensembl ID		ENSG00000137203	ENSG00000065978
Uniprot IDs		P05549	P67809
PDB IDs			1H95 5YTS 5YTT 5YTV 5YTX 6A6L 6KTC 6KUG 6LMR 6LMS
Enriched GO Terms of Interacting Partners?
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