MAST1 and RNLS

Data Source:
BioGRID (two hybrid)

		MAST1	RNLS
Description		microtubule associated serine/threonine kinase 1	renalase, FAD dependent amine oxidase
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Axon Dendrite Neuron Projection Neuronal Cell Body	Extracellular Region Extracellular Space
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Oxidoreductase Activity, Acting On NAD(P)H Epinephrine Binding NADH Binding Monoamine Oxidase Activity
	Biological Process	Protein Phosphorylation Cytoskeleton Organization Brain Development Peptidyl-serine Phosphorylation Intracellular Signal Transduction	Response To Ischemia Negative Regulation Of Heart Rate NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Negative Regulation Of Blood Pressure Response To Epinephrine Response To Salt
Pathways			Nicotinamide salvaging
Drugs		Fostamatinib
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Red blood cell count ( 29403010) Reticulocyte fraction of red cells ( 32888494)	Birth weight ( 31043758) Cortical amyloid beta load ( 29860282) Depressive and manic episodes in bipolar disorder ( 26297903) End stage renal disease in APOL1 risk genotype-negative individuals ( 29885931) Estimated glomerular filtration rate in coronary artery disease and impaired kidney function ( 30809046) Familial lung adenocarcinoma ( 29924316) Height ( 31562340) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mercury levels ( 26025379) Prostate cancer ( 29892016) Pulse pressure ( 27841878) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Thyroid stimulating hormone levels ( 32769997) Type 1 diabetes ( 30659077 30572963) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		40 interacting genes: A2M AP1M2 APOE APP BLMH CDK5 CYP2C8 CYP2C9 DNAJB1 ECSIT EGFR ELAVL3 EXOC6 EXOSC1 FBXL12 FBXW4 GCDH HSP90AB1 IFIT3 IFIT5 LONP1 LOXL4 NOS3 OGA PAXIP1 PRAM1 PRDX2 PSEN2 PTEN RAB3A RAB3D RAD23A RNF32 RNLS RPP30 RPS6KA1 SNTA1 SNTB2 STAMBPL1 UBE2D3	2 interacting genes: FAM107A MAST1
Entrez ID		22983	55328
HPRD ID		17469	07742
Ensembl ID		ENSG00000105613	ENSG00000184719
Uniprot IDs		Q9Y2H9	B4DJW3 Q5VYX0
PDB IDs		2M9X 3PS4	3QJ4
Enriched GO Terms of Interacting Partners?
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