MAST1 and LOXL4

Data Source:
BioGRID (two hybrid)

		MAST1	LOXL4
Description		microtubule associated serine/threonine kinase 1	lysyl oxidase like 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Axon Dendrite Neuron Projection Neuronal Cell Body	Extracellular Space Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein-lysine 6-oxidase Activity Scavenger Receptor Activity Copper Ion Binding Protein Binding
	Biological Process	Protein Phosphorylation Cytoskeleton Organization Brain Development Peptidyl-serine Phosphorylation Intracellular Signal Transduction	Endocytosis Peptidyl-lysine Oxidation Protein Phosphopantetheinylation Collagen Fibril Organization
Pathways			Elastic fibre formation Crosslinking of collagen fibrils
Drugs		Fostamatinib
Diseases
GWAS		High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Red blood cell count ( 29403010) Reticulocyte fraction of red cells ( 32888494)	Body mass index ( 29273807) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Height ( 31562340) Multiple system atrophy ( 27629089)
Interacting Genes		40 interacting genes: A2M AP1M2 APOE APP BLMH CDK5 CYP2C8 CYP2C9 DNAJB1 ECSIT EGFR ELAVL3 EXOC6 EXOSC1 FBXL12 FBXW4 GCDH HSP90AB1 IFIT3 IFIT5 LONP1 LOXL4 NOS3 OGA PAXIP1 PRAM1 PRDX2 PSEN2 PTEN RAB3A RAB3D RAD23A RNF32 RNLS RPP30 RPS6KA1 SNTA1 SNTB2 STAMBPL1 UBE2D3	15 interacting genes: AP1M2 APOE CDC37 COL2A1 ECSIT EXOC6 KDM1A LONP1 MAST1 MTDH PRMT6 RAD23A RNF32 SUV39H1 TRIP13
Entrez ID		22983	84171
HPRD ID		17469	09538
Ensembl ID		ENSG00000105613	ENSG00000138131
Uniprot IDs		Q9Y2H9	Q96JB6
PDB IDs		2M9X 3PS4
Enriched GO Terms of Interacting Partners?
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