RABEP1 and ATXN7

Number of citations of the paper that reports this interaction (PubMedID 21078624)
23

Data Source:
BioGRID (two hybrid)

		RABEP1	ATXN7
Description		rabaptin, RAB GTPase binding effector protein 1	ataxin 7
Image
GO Annotations	Cellular Component	Endosome Early Endosome Endocytic Vesicle Early Endosome Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Recycling Endosome	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix
	Molecular Function	GTPase Activator Activity Protein Binding Growth Factor Activity Protein Domain Specific Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Golgi To Plasma Membrane Transport Endocytosis Apoptotic Process Signal Transduction Protein Transport Vesicle-mediated Transport Positive Regulation Of GTPase Activity Membrane Fusion Protein Localization To Ciliary Membrane	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination Protein Deubiquitination
Pathways		TBC/RABGAPs	HATs acetylate histones Ub-specific processing proteases
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Body mass index ( 28892062 25673413) Red blood cell density in sickle cell anemia ( 28552477) White blood cell count ( 27863252)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30054458)
Interacting Genes		24 interacting genes: AP1G1 AP1G2 ATXN7 CASP3 CCND1 GAP43 GGA1 GGA2 GGA3 HUNK ITSN1 ITSN2 RAB1A RAB33B RAB4A RAB5A RABGEF1 RGS17 SMURF1 SRPK2 TRIM26 TSC2 UBC YWHAG	60 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN IMPDH2 ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF
Entrez ID		9135	6314
HPRD ID		04684	06365
Ensembl ID		ENSG00000029725	ENSG00000163635
Uniprot IDs		B4DMM4 Q15276	O15265 Q9UPD8
PDB IDs		1P4U 1TU3 1X79 4N3Y 4N3Z 4Q9U	2KKR
Enriched GO Terms of Interacting Partners?
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