ATXN7 and THY1

Number of citations of the paper that reports this interaction (PubMedID 21078624)
23

Data Source:
BioGRID (two hybrid)

		ATXN7	THY1
Description		ataxin 7	Thy-1 cell surface antigen
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix	Extracellular Region Cell Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Apical Plasma Membrane Dendrite Growth Cone Axolemma Anchored Component Of External Side Of Plasma Membrane Dendrite Membrane Neuronal Cell Body Membrane Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding	GTPase Activator Activity Integrin Binding Protein Binding Protein Kinase Binding GPI Anchor Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination Protein Deubiquitination	Angiogenesis Regulation Of Cell-matrix Adhesion Positive Regulation Of Cellular Extravasation Negative Regulation Of Protein Kinase Activity Cytoskeleton Organization Integrin-mediated Signaling Pathway Cell-cell Signaling Negative Regulation Of Cell Migration Positive Regulation Of Heterotypic Cell-cell Adhesion Receptor Clustering Positive Regulation Of GTPase Activity Retinal Cone Cell Development Protein Autophosphorylation Focal Adhesion Assembly Negative Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Neuron Projection Regeneration Cell-cell Adhesion Regulation Of Rho-dependent Protein Serine/threonine Kinase Activity
Pathways		HATs acetylate histones Ub-specific processing proteases	Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30054458)
Interacting Genes		60 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN IMPDH2 ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF	8 interacting genes: ATXN1L ATXN7 CLK1 FYN ITGAM ITGAV ITGB3 LCK
Entrez ID		6314	7070
HPRD ID		06365	01769
Ensembl ID		ENSG00000163635	ENSG00000154096
Uniprot IDs		O15265 Q9UPD8	B0YJA4 P04216
PDB IDs		2KKR
Enriched GO Terms of Interacting Partners?
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