ATXN7 and USP22

Number of citations of the paper that reports this interaction (PubMedID 26195632)
6

Data Source:
BioGRID (pull down)

		ATXN7	USP22
Description		ataxin 7	ubiquitin specific peptidase 22
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix	SAGA Complex Nucleoplasm SAGA-type Complex
	Molecular Function	Protein Binding	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding H4 Histone Acetyltransferase Activity Enzyme Binding Nuclear Receptor Transcription Coactivator Activity
	Biological Process	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination Protein Deubiquitination	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Embryo Development Ending In Birth Or Egg Hatching Histone Ubiquitination Histone Deubiquitination Protein Deubiquitination Histone H4 Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle
Pathways		HATs acetylate histones Ub-specific processing proteases	HATs acetylate histones Ub-specific processing proteases
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30054458)	Body mass index ( 26426971) Mosquito bite size ( 28199695)
Interacting Genes		60 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN IMPDH2 ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF	12 interacting genes: ATXN7 H2AC20 H2BC21 HEXA MRPL10 MRPL44 MYC PSME1 PTGS2 RCAN1 SCFD1 UBC
Entrez ID		6314	23326
HPRD ID		06365	19411
Ensembl ID		ENSG00000163635	ENSG00000124422
Uniprot IDs		O15265 Q9UPD8	Q9UPT9
PDB IDs		2KKR
Enriched GO Terms of Interacting Partners?
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