ATXN7 and UBQLN2

Number of citations of the paper that reports this interaction (PubMedID 21078624)
23

Data Source:
BioGRID (two hybrid)

		ATXN7	UBQLN2
Description		ataxin 7	ubiquilin 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix	Nucleus Cytoplasm Autophagosome Cytosol Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Protein Binding	Protein Binding Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination Protein Deubiquitination	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Regulation Of Macroautophagy Ubiquitin-dependent ERAD Pathway Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Autophagosome Assembly
Pathways		HATs acetylate histones Ub-specific processing proteases	Cargo recognition for clathrin-mediated endocytosis
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30054458)
Interacting Genes		60 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN IMPDH2 ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF	22 interacting genes: ADRM1 ATXN7 BTRC C1QA CD93 FBXO25 FUS HERC3 HERPUD1 HNRNPA3 HSPA13 MTNR1B PRPF40A PSMA2 PSMA5 PSMD4 RNF11 RPN1 SMURF1 UBC UBE3A UBQLN4
Entrez ID		6314	29978
HPRD ID		06365	02224
Ensembl ID		ENSG00000163635	ENSG00000188021
Uniprot IDs		O15265 Q9UPD8	Q9UHD9
PDB IDs		2KKR	1J8C 2NBV 6MUN
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?