EIF3F and CDK19

Number of citations of the paper that reports this interaction (PubMedID 12446680)
30

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		EIF3F	CDK19
Description		eukaryotic translation initiation factor 3 subunit F	cyclin dependent kinase 19
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Nucleus Cytosol Mediator Complex
	Molecular Function	Translation Initiation Factor Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Translation Initiation Factor Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Protein Deubiquitination IRES-dependent Viral Translational Initiation	Protein Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Inflammatory Response Regulation Of Cell Cycle Cellular Response To Lipopolysaccharide
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs		Quercetin
Diseases
GWAS		Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depression (quantitative trait) ( 20800221)	General risk tolerance (MTAG) ( 30643258) Zinc levels ( 26025379)
Interacting Genes		19 interacting genes: APP ATXN1 CDK11A CDK11B CDK19 DKC1 EEF1A1 EIF3M FBXO32 HAX1 HNRNPK HTR2A MCPH1 MSH4 MTOR PTN RPS6KB1 SHBG SMAD9	8 interacting genes: BCL6 EIF3F PRMT5 SMARCA4 SRSF7 SUZ12 USP54 WDR77
Entrez ID		8665	23097
HPRD ID		04887	07627
Ensembl ID		ENSG00000175390	ENSG00000155111
Uniprot IDs		O00303	B4DUB1 I6W807 Q9BWU1
PDB IDs		3J8B 3J8C
Enriched GO Terms of Interacting Partners?
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