CDK19 and EIF3F

Number of citations of the paper that reports this interaction (PubMedID 12446680)
30

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		CDK19	EIF3F
Description		cyclin dependent kinase 19	eukaryotic translation initiation factor 3 subunit F
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Mediator Complex	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Eukaryotic Translation Initiation Factor 3 Complex, EIF3m
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity	Translation Initiation Factor Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Translation Initiation Factor Binding
	Biological Process	Protein Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Inflammatory Response Regulation Of Cell Cycle Cellular Response To Lipopolysaccharide	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Protein Deubiquitination IRES-dependent Viral Translational Initiation
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs			Quercetin
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Zinc levels ( 26025379)	Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depression (quantitative trait) ( 20800221)
Interacting Genes		8 interacting genes: BCL6 EIF3F PRMT5 SMARCA4 SRSF7 SUZ12 USP54 WDR77	19 interacting genes: APP ATXN1 CDK11A CDK11B CDK19 DKC1 EEF1A1 EIF3M FBXO32 HAX1 HNRNPK HTR2A MCPH1 MSH4 MTOR PTN RPS6KB1 SHBG SMAD9
Entrez ID		23097	8665
HPRD ID		07627	04887
Ensembl ID		ENSG00000155111	ENSG00000175390
Uniprot IDs		B4DUB1 I6W807 Q9BWU1	O00303
PDB IDs			3J8B 3J8C
Enriched GO Terms of Interacting Partners?
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