SRP54 and EGLN3

		SRP54	EGLN3
Description		signal recognition particle 54	egl-9 family hypoxia inducible factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding GTPase Activity Protein Binding GTP Binding Drug Binding 7S RNA Binding GDP Binding Endoplasmic Reticulum Signal Peptide Binding Ribonucleoprotein Complex Binding	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity
	Biological Process	SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Response To Drug Protein Targeting To ER	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Proliferation Regulation Of Neuron Apoptotic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pathways		SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs			Vitamin C Roxadustat
Diseases
GWAS		Heel bone mineral density ( 30598549) Immunoglobulin light chain (AL) amyloidosis ( 28025584)	Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 27863252)
Interacting Genes		8 interacting genes: EGLN3 KLK12 PRORP RALGAPA1 RNPS1 SRP19 STAB1 TKTL1	25 interacting genes: ABI2 ADRB2 ATF4 EFHC2 EPAS1 EPOR FOXJ2 HIF1A HIF3A IKBKG MAPK1 MAPK7 NCAPH2 OS9 PKM PRPF19 SERTAD1 SIAH2 SRP54 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83
Entrez ID		6729	112399
HPRD ID		05330	06972
Ensembl ID		ENSG00000100883	ENSG00000129521
Uniprot IDs		P61011	B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9
PDB IDs		1MFQ 1QB2 5L3Q
Enriched GO Terms of Interacting Partners?
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