EGLN3 and EFHC2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		EGLN3	EFHC2
Description		egl-9 family hypoxia inducible factor 3	EF-hand domain containing 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Microtubule
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity	Calcium Ion Binding Protein Binding
	Biological Process	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Proliferation Regulation Of Neuron Apoptotic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Regulation Of Neuron Projection Development Cellular Response To Leukemia Inhibitory Factor
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs		Vitamin C Roxadustat
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 27863252)	Mean arterial pressure ( 29403010)
Interacting Genes		25 interacting genes: ABI2 ADRB2 ATF4 EFHC2 EPAS1 EPOR FOXJ2 HIF1A HIF3A IKBKG MAPK1 MAPK7 NCAPH2 OS9 PKM PRPF19 SERTAD1 SIAH2 SRP54 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83	37 interacting genes: ARHGEF5 ARMC7 CACNB4 CCDC120 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CYFIP1 DGCR6 EDC3 EFHC1 EGLN3 EMD EXOC8 FAM107A HNRNPLL JAKMIP2 KIF9 LONRF1 MAPK9 NCDN NCK2 NDOR1 NR3C1 PBLD PLOD3 PTK6 RAD51D RUNX1T1 SNRNP25 SPG21 STK16 TRIM42 TSSK3 TUBGCP4
Entrez ID		112399	80258
HPRD ID		06972	06540
Ensembl ID		ENSG00000129521	ENSG00000183690
Uniprot IDs		B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9	Q5JST6
PDB IDs			2Z13 2Z14
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?