EGLN3 and TTC23L

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		EGLN3	TTC23L
Description		egl-9 family hypoxia inducible factor 3	tetratricopeptide repeat domain 23 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Microtubule Organizing Center Spindle Midbody
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity	Protein Binding
	Biological Process	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Proliferation Regulation Of Neuron Apoptotic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Response To Endoplasmic Reticulum Stress
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs		Vitamin C Roxadustat
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 27863252)	Daytime sleep phenotypes ( 27126917) Dysphagia ( 26116289)
Interacting Genes		25 interacting genes: ABI2 ADRB2 ATF4 EFHC2 EPAS1 EPOR FOXJ2 HIF1A HIF3A IKBKG MAPK1 MAPK7 NCAPH2 OS9 PKM PRPF19 SERTAD1 SIAH2 SRP54 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83	6 interacting genes: CALCOCO2 CBY1 EGLN3 EXOC5 MIA2 UBE3A
Entrez ID		112399	153657
HPRD ID		06972	08691
Ensembl ID		ENSG00000129521	ENSG00000205838
Uniprot IDs		B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9	A0A3B3IS63 Q6PF05
PDB IDs
Enriched GO Terms of Interacting Partners?
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