EGLN3 and HIF3A

Number of citations of the paper that reports this interaction (PubMedID 15474027)
27

Data Source:
HPRD (in vitro)

		EGLN3	HIF3A
Description		egl-9 family hypoxia inducible factor 3	hypoxia inducible factor 3 subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Mitochondrion Cytosol Plasma Membrane Nuclear Speck
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Dimerization Activity
	Biological Process	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Proliferation Regulation Of Neuron Apoptotic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia	Angiogenesis Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Protein Ubiquitination Post-translational Protein Modification Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Regulation of gene expression by Hypoxia-inducible Factor Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Transcriptional regulation of pluripotent stem cells Neddylation
Drugs		Vitamin C Roxadustat
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 27863252)	Free cholesterol levels in medium VLDL ( 29084231) Medium VLDL particle concentration ( 29084231) Phospholipid levels in large VLDL ( 29084231) Phospholipid levels in medium VLDL ( 29084231) Phospholipid levels in small VLDL ( 29084231) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy) ( 24554482) Small VLDL particle concentration ( 29084231) Total cholesterol levels in medium VLDL ( 29084231) Total triglycerides levels ( 29084231) Triglyceride levels in large VLDL ( 29084231) Triglyceride levels in medium VLDL ( 29084231) Triglyceride levels in small VLDL ( 29084231) Very large VLDL particle concentration ( 29084231) Weight ( 28552196)
Interacting Genes		25 interacting genes: ABI2 ADRB2 ATF4 EFHC2 EPAS1 EPOR FOXJ2 HIF1A HIF3A IKBKG MAPK1 MAPK7 NCAPH2 OS9 PKM PRPF19 SERTAD1 SIAH2 SRP54 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83	7 interacting genes: ARNT EGLN1 EGLN2 EGLN3 HIF1A HSP90AA1 VHL
Entrez ID		112399	64344
HPRD ID		06972	17104
Ensembl ID		ENSG00000129521	ENSG00000124440
Uniprot IDs		B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9	B2RBI6 H0YDZ5 M0R104 Q9Y2N7
PDB IDs			4WN5
Enriched GO Terms of Interacting Partners?
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