SPTB and SH2D2A

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		SPTB	SH2D2A
Description		spectrin beta, erythrocytic	SH2 domain containing 2A
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Protein-containing Complex	Cytoplasm Cytosol
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Ankyrin Binding Actin Filament Binding	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Signaling Adaptor Activity
	Biological Process	MAPK Cascade ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axon Guidance Actin Filament Capping	Angiogenesis Signal Transduction Cell Proliferation Positive Regulation Of Signal Transduction Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	VEGFA-VEGFR2 Pathway
Drugs
Diseases		Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH)
GWAS		Daytime sleep phenotypes ( 27126917) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Obesity-related traits ( 23251661) Pediatric areal bone mineral density (radius) ( 28181694) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Type 2 diabetes ( 31049640)	Platelet count ( 27863252) SjÃ¶gren's syndrome ( 28076899)
Interacting Genes		14 interacting genes: ACTB ADD1 ANK1 AP1G1 CSRP3 DMTN EPB41 MAPT NCAM1 SH2D2A SPTA1 SPTAN1 STAT1 YWHAQ	29 interacting genes: APPL1 ARID5A CRK DAPK1 EGFR ERBB2 ITK KDR LCK LINC02875 LNX1 LRRFIP1 LRRK1 MAP3K2 MAPK7 MFHAS1 NAA16 PLCG1 PPP1R21 SOCS3 SPTB STAT3 SYK TSC1 TXK VCP ZHX3 ZSCAN1 ZYG11B
Entrez ID		6710	9047
HPRD ID		01686	05152
Ensembl ID		ENSG00000070182	ENSG00000027869
Uniprot IDs		P11277	Q5UBZ2 Q5UBZ3 Q9NP31
PDB IDs		1S35 3EDU 3F57 3KBT 3KBU 3LBX
Enriched GO Terms of Interacting Partners?
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