SPTB and ANK1

Number of citations of the paper that reports this interaction (PubMedID 2141335)
29

Data Source:
BioGRID (pull down)

		SPTB	ANK1
Description		spectrin beta, erythrocytic	ankyrin 1
Image
GO Annotations	Cellular Component	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Protein-containing Complex	Nucleus Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Spectrin-associated Cytoskeleton Membrane Basolateral Plasma Membrane Sarcoplasmic Reticulum Z Disc Axolemma M Band Sarcolemma Axon Initial Segment Postsynaptic Membrane
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Ankyrin Binding Actin Filament Binding	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Adaptor Activity Enzyme Binding Protein Phosphatase Binding Spectrin Binding Ion Channel Binding ATPase Binding
	Biological Process	MAPK Cascade ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axon Guidance Actin Filament Capping	Exocytosis ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Signal Transduction Positive Regulation Of Organelle Organization Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Plasma Membrane
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins NrCAM interactions CHL1 interactions Neurofascin interactions Neurofascin interactions COPI-mediated anterograde transport
Drugs
Diseases		Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH)	Hereditary spherocytosis (SPH)
GWAS		Daytime sleep phenotypes ( 27126917) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Obesity-related traits ( 23251661) Pediatric areal bone mineral density (radius) ( 28181694) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Type 2 diabetes ( 31049640)	Birth weight ( 31043758 27680694) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Glycated hemoglobin levels ( 24647736 20858683 31213470 28898252) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Insulin levels adjusted for BMI ( 24699409) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252 28017375) Mean corpuscular volume ( 27863252) Neutrophil percentage of white cells ( 27863252) Pulmonary function decline ( 22424883) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Sleep duration ( 30531941) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 26818947 30718926 28869590 22456796)
Interacting Genes		14 interacting genes: ACTB ADD1 ANK1 AP1G1 CSRP3 DMTN EPB41 MAPT NCAM1 SH2D2A SPTA1 SPTAN1 STAT1 YWHAQ	19 interacting genes: BLOC1S6 CD44 EPB42 HSPB1 ITPR3 KCTD6 L1CAM NBPF3 NFASC OBSCN RHAG RYR1 SLC4A1 SLC4A3 SPTA1 SPTAN1 SPTB TIAM1 TTN
Entrez ID		6710	286
HPRD ID		01686	01693
Ensembl ID		ENSG00000070182	ENSG00000029534
Uniprot IDs		P11277	B3KX39 P16157
PDB IDs		1S35 3EDU 3F57 3KBT 3KBU 3LBX	1N11 2YQF 2YVI 3F59 3KBT 3KBU 3UD1 3UD2
Enriched GO Terms of Interacting Partners?
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