SPTB and AP1G1

Number of citations of the paper that reports this interaction (PubMedID 10477754)
47

Data Source:
HPRD (two hybrid)

		SPTB	AP1G1
Description		spectrin beta, erythrocytic	adaptor related protein complex 1 subunit gamma 1
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GO Annotations	Cellular Component	Cytosol Spectrin Spectrin-associated Cytoskeleton Actin Cytoskeleton Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane Protein-containing Complex	Golgi Membrane Cytoplasm Lysosomal Membrane Golgi Apparatus Cytosol Membrane AP-1 Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Ankyrin Binding Actin Filament Binding	Protein Binding Rab GTPase Binding Kinesin Binding GTP-dependent Protein Binding
	Biological Process	MAPK Cascade ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axon Guidance Actin Filament Capping	Intracellular Protein Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Organization Endosome To Melanosome Transport Positive Regulation Of Natural Killer Cell Degranulation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Defense Response To Virus By Virus Golgi To Lysosome Transport
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases		Hereditary elliptocytosis (HE) Hereditary spherocytosis (SPH)
GWAS		Daytime sleep phenotypes ( 27126917) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252) Obesity-related traits ( 23251661) Pediatric areal bone mineral density (radius) ( 28181694) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Type 2 diabetes ( 31049640)	General cognitive ability ( 29844566) Post bronchodilator FEV1 ( 26634245) Superior temporal sulcus banks volume ( 31530798)
Interacting Genes		14 interacting genes: ACTB ADD1 ANK1 AP1G1 CSRP3 DMTN EPB41 MAPT NCAM1 SH2D2A SPTA1 SPTAN1 STAT1 YWHAQ	24 interacting genes: AFTPH AP1AR AP1B1 AP1M2 AP1S1 AP1S2 ARF1 ARFRP1 BAALC CLINT1 CLTC DNER EPS15 KIF13A MAP1A PSEN2 RABEP1 RABGEF1 SPTB SYNRG SYP UBL7 UPF1 ZNF512B
Entrez ID		6710	164
HPRD ID		01686	04637
Ensembl ID		ENSG00000070182	ENSG00000166747
Uniprot IDs		P11277	A0A140VJE7 O43747 Q8IY97
PDB IDs		1S35 3EDU 3F57 3KBT 3KBU 3LBX	1IU1
Enriched GO Terms of Interacting Partners?
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