SFTPC and PQBP1

Number of citations of the paper that reports this interaction (PubMedID 19366705)
8

Data Source:
BioGRID (pull down)

		SFTPC	PQBP1
Description		surfactant protein C	polyglutamine binding protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Multivesicular Body Lumen	Nucleus Nucleoplasm Cytosol Cytoplasmic Stress Granule Nuclear Speck Neuronal Ribonucleoprotein Granule
	Molecular Function	Protein Binding Identical Protein Binding	DNA Binding Double-stranded DNA Binding Transcription Coactivator Activity Protein Binding Ribonucleoprotein Complex Binding
	Biological Process	Respiratory Gaseous Exchange Cellular Protein Metabolic Process	Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Regulation Of Transcription, DNA-templated Neuron Projection Development Positive Regulation Of Type I Interferon Production Regulation Of RNA Splicing Innate Immune Response Regulation Of Dendrite Morphogenesis Defense Response To Virus Cellular Response To Exogenous DsRNA Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Surfactant metabolism Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS) Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)	mRNA Splicing - Major Pathway
Drugs
Diseases		Pulmonary surfactant metabolism dysfunction (SMDP)	Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Non-syndromic X-linked mental retardation
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323)
Interacting Genes		12 interacting genes: CREB3 CXCL9 LMNA NEDD4 PQBP1 SEC22A SEC61G SMIM3 SYNE4 TMEM79 WWP1 WWP2	24 interacting genes: APBB1 APP AQR ATXN1 CLTB EEF1A1 ERG28 ESR1 GOLGA2 HNRNPH2 LNX1 LRIF1 LZTS2 MAPRE1 MED31 POLR2A POU3F2 RAB8A RCVRN SFTPC TLX3 TXNL4A WBP11 WDR77
Entrez ID		6440	10084
HPRD ID		01520	02354
Ensembl ID		ENSG00000168484	ENSG00000102103
Uniprot IDs		A0A0A0MTC9 A0A0S2Z4Q0 E5RI64 P11686	A0A0S2Z4V5 O60828
PDB IDs		2YAD	4BWQ 4BWS 4CDO
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?