PQBP1 and SFTPC

Number of citations of the paper that reports this interaction (PubMedID 19366705)
8

Data Source:
BioGRID (pull down)

		PQBP1	SFTPC
Description		polyglutamine binding protein 1	surfactant protein C
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Cytoplasmic Stress Granule Nuclear Speck Neuronal Ribonucleoprotein Granule	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Lamellar Body Clathrin-coated Endocytic Vesicle Multivesicular Body Lumen
	Molecular Function	DNA Binding Double-stranded DNA Binding Transcription Coactivator Activity Protein Binding Ribonucleoprotein Complex Binding	Protein Binding Identical Protein Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Regulation Of Transcription, DNA-templated Neuron Projection Development Positive Regulation Of Type I Interferon Production Regulation Of RNA Splicing Innate Immune Response Regulation Of Dendrite Morphogenesis Defense Response To Virus Cellular Response To Exogenous DsRNA Positive Regulation Of Nucleic Acid-templated Transcription	Respiratory Gaseous Exchange Cellular Protein Metabolic Process
Pathways		mRNA Splicing - Major Pathway	Surfactant metabolism Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS) Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4)
Drugs
Diseases		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) Non-syndromic X-linked mental retardation	Pulmonary surfactant metabolism dysfunction (SMDP)
GWAS			Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323)
Interacting Genes		24 interacting genes: APBB1 APP AQR ATXN1 CLTB EEF1A1 ERG28 ESR1 GOLGA2 HNRNPH2 LNX1 LRIF1 LZTS2 MAPRE1 MED31 POLR2A POU3F2 RAB8A RCVRN SFTPC TLX3 TXNL4A WBP11 WDR77	12 interacting genes: CREB3 CXCL9 LMNA NEDD4 PQBP1 SEC22A SEC61G SMIM3 SYNE4 TMEM79 WWP1 WWP2
Entrez ID		10084	6440
HPRD ID		02354	01520
Ensembl ID		ENSG00000102103	ENSG00000168484
Uniprot IDs		A0A0S2Z4V5 O60828	A0A0A0MTC9 A0A0S2Z4Q0 E5RI64 P11686
PDB IDs		4BWQ 4BWS 4CDO	2YAD
Enriched GO Terms of Interacting Partners?
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