EGLN1 and PLD1

Number of citations of the paper that reports this interaction (PubMedID 25361009)
9

Data Source:
BioGRID (pull down, affinity chromatography technology)

		EGLN1	PLD1
Description		egl-9 family hypoxia inducible factor 1	phospholipase D1
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Cytosol Postsynaptic Density Glutamatergic Synapse	Golgi Membrane Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Late Endosome Membrane Specific Granule Membrane Perinuclear Region Of Cytoplasm Tertiary Granule Membrane Cholinergic Synapse
	Molecular Function	Protein Binding Ferrous Iron Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Enzyme Binding L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity
	Biological Process	Response To Hypoxia Cellular Iron Ion Homeostasis Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Oxygen Homeostasis Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Cardiac Muscle Tissue Morphogenesis Oxidation-reduction Process Heart Trabecula Formation Ventricular Septum Morphogenesis Labyrinthine Layer Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Nitric Oxide Regulation Of Postsynapse Organization Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Regulation Of Neuron Death	Phosphatidic Acid Biosynthetic Process Chemotaxis Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Lipid Catabolic Process Regulation Of Microvillus Assembly Neutrophil Degranulation Positive Regulation Of Translation Inositol Lipid-mediated Signaling Cell Motility Regulation Of Synaptic Vesicle Cycle
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis Neutrophil degranulation
Drugs		Vitamin C Iron Roxadustat N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE	Choline LAX-101
Diseases		Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) High altitude adaptation ( 28373541) Metabolite levels ( 23823483) Red blood cell count ( 27863252)	Cerebrospinal fluid AB1-42 levels ( 29274321) Red cell distribution width ( 27863252 28957414)
Interacting Genes		13 interacting genes: EPAS1 FKBP8 HIF1A HIF3A HSP90AA1 HSP90AB1 ING4 KRAS OS9 PLD1 SRC VHL ZNF281	26 interacting genes: ACTA1 ACTB ACTG1 ARF1 ARF6 ARIH1 BIN1 CAV1 CDC42 EGFR EGLN1 HIF1A PEA15 PIP5K1A PKN1 PKN3 PRKCA RAC1 RALA RHEB RHOA RHOG SNCA SRC STXBP1 VHL
Entrez ID		54583	5337
HPRD ID		06971	03855
Ensembl ID		ENSG00000135766	ENSG00000075651
Uniprot IDs		Q9GZT9 R4SCQ0	Q13393 Q59EA4
PDB IDs		2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4JZR 4KBZ 4UWD 5A3U 5L9B 5L9R 5L9V 5LA9 5LAS 5LAT 5LB6 5LBB 5LBC 5LBE 5LBF 5OX5 5OX6 5V18 6NMQ
Enriched GO Terms of Interacting Partners?
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