EGLN1 and ZNF281

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		EGLN1	ZNF281
Description		egl-9 family hypoxia inducible factor 1	zinc finger protein 281
Image			No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Cytosol Postsynaptic Density Glutamatergic Synapse	Nucleus Nucleoplasm
	Molecular Function	Protein Binding Ferrous Iron Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Enzyme Binding L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Cellular Iron Ion Homeostasis Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Oxygen Homeostasis Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Cardiac Muscle Tissue Morphogenesis Oxidation-reduction Process Heart Trabecula Formation Ventricular Septum Morphogenesis Labyrinthine Layer Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Nitric Oxide Regulation Of Postsynapse Organization Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Regulation Of Neuron Death	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Embryonic Body Morphogenesis Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Stem Cell Differentiation
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs		Vitamin C Iron Roxadustat N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Diseases		Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) High altitude adaptation ( 28373541) Metabolite levels ( 23823483) Red blood cell count ( 27863252)	Antisaccade task score ( 31596458) Myopia ( 27182965) Neurofibrillary tangles ( 31497858) Prepulse inhibition of the startle response ( 31596458)
Interacting Genes		13 interacting genes: EPAS1 FKBP8 HIF1A HIF3A HSP90AA1 HSP90AB1 ING4 KRAS OS9 PLD1 SRC VHL ZNF281	7 interacting genes: CD247 EGLN1 FBXW11 MYC PIK3R3 STAT3 ZBTB16
Entrez ID		54583	23528
HPRD ID		06971	11702
Ensembl ID		ENSG00000135766	ENSG00000162702
Uniprot IDs		Q9GZT9 R4SCQ0	B3KMX4 Q9Y2X9
PDB IDs		2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4JZR 4KBZ 4UWD 5A3U 5L9B 5L9R 5L9V 5LA9 5LAS 5LAT 5LB6 5LBB 5LBC 5LBE 5LBF 5OX5 5OX6 5V18 6NMQ
Enriched GO Terms of Interacting Partners?
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