EGLN1 and FKBP8

Number of citations of the paper that reports this interaction (PubMedID 27770548)
1

Data Source:
BioGRID (two hybrid)

		EGLN1	FKBP8
Description		egl-9 family hypoxia inducible factor 1	FKBP prolyl isomerase 8
Image
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Cytosol Postsynaptic Density Glutamatergic Synapse	Mitochondrion Endoplasmic Reticulum Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane Mitochondrial Membrane Protein-containing Complex
	Molecular Function	Protein Binding Ferrous Iron Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors Enzyme Binding L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Identical Protein Binding Protein Binding Involved In Protein Folding Metal Ion Binding Disordered Domain Specific Binding
	Biological Process	Response To Hypoxia Cellular Iron Ion Homeostasis Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Oxygen Homeostasis Negative Regulation Of DNA-binding Transcription Factor Activity Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Cardiac Muscle Tissue Morphogenesis Oxidation-reduction Process Heart Trabecula Formation Ventricular Septum Morphogenesis Labyrinthine Layer Development Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Nitric Oxide Regulation Of Postsynapse Organization Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Regulation Of Neuron Death	Protein Peptidyl-prolyl Isomerization Cell Fate Specification Negative Regulation Of Protein Phosphorylation Protein Folding Apoptotic Process Smoothened Signaling Pathway Viral Process Dorsal/ventral Neural Tube Patterning Positive Regulation Of BMP Signaling Pathway Multicellular Organism Growth Intracellular Signal Transduction Camera-type Eye Development Negative Regulation Of Apoptotic Process
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Ub-specific processing proteases
Drugs		Vitamin C Iron Roxadustat N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE N-[(1-CHLORO-4-HYDROXYISOQUINOLIN-3-YL)CARBONYL]GLYCINE
Diseases		Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) High altitude adaptation ( 28373541) Metabolite levels ( 23823483) Red blood cell count ( 27863252)	Plasma parathyroid hormone levels ( 30134803) Urinary potassium excretion ( 31409800)
Interacting Genes		13 interacting genes: EPAS1 FKBP8 HIF1A HIF3A HSP90AA1 HSP90AB1 ING4 KRAS OS9 PLD1 SRC VHL ZNF281	17 interacting genes: ANKMY2 ARHGEF5 ATP13A2 BCL2 BCL2L1 BNIPL CLCN1 EGFR EGLN1 MAPK14 MTOR PPP3CA PSMC1 PSMD2 RHEB TERF1 VHL
Entrez ID		54583	23770
HPRD ID		06971	05327
Ensembl ID		ENSG00000135766	ENSG00000105701
Uniprot IDs		Q9GZT9 R4SCQ0	A0A024R7P2 B2R8G6 Q14318
PDB IDs		2G19 2G1M 2HBT 2HBU 2Y33 2Y34 3HQR 3HQU 3OUH 3OUI 3OUJ 4BQW 4BQX 4BQY 4JZR 4KBZ 4UWD 5A3U 5L9B 5L9R 5L9V 5LA9 5LAS 5LAT 5LB6 5LBB 5LBC 5LBE 5LBF 5OX5 5OX6 5V18 6NMQ	2AWG 2D9F 2F2D 2MF9 3EY6 5MGX
Enriched GO Terms of Interacting Partners?
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