KLHL15 and PPP2R2B

Number of citations of the paper that reports this interaction (PubMedID 23135275)
15

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		KLHL15	PPP2R2B
Description		kelch like family member 15	protein phosphatase 2 regulatory subunit Bbeta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cul3-RING Ubiquitin Ligase Complex	Protein Phosphatase Type 2A Complex Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton
	Molecular Function	Protein Binding	Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Nuclear Protein Quality Control By The Ubiquitin-proteasome System Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Peptidyl-serine Dephosphorylation
Pathways
Drugs
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Prostate-specific antigen levels ( 28139693)	Alcohol dependence ( 19581569) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Night sleep phenotypes ( 27126917) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Schizophrenia ( 30285260) Urate levels in lean individuals ( 25811787)
Interacting Genes		3 interacting genes: POLA1 PPP2R2B RBBP8	6 interacting genes: CDK1 CHEK2 KLHL15 RAC1 TOP1 TP53
Entrez ID		80311	5521
HPRD ID		09957	05059
Ensembl ID		ENSG00000174010	ENSG00000156475
Uniprot IDs		Q96M94 V9HWF1	Q00005
PDB IDs
Enriched GO Terms of Interacting Partners?
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