EVL and ABI1

Number of citations of the paper that reports this interaction (PubMedID 16055720)
81

Data Source:
HPRD (in vivo, in vitro)

		EVL	ABI1
Description		Enah/Vasp-like	abl interactor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium Phagocytic Vesicle	Intracellular Nucleus Endoplasmic Reticulum Cytosol Cytoskeleton Plasma Membrane Postsynaptic Density Aggresome Lamellipodium Cell Junction Growth Cone SCAR Complex Filopodium Tip Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Cadherin Binding
	Biological Process	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Cellular Response To Interferon-gamma Negative Regulation Of Ruffle Assembly	Somitogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Polymerization Or Depolymerization Negative Regulation Of Cell Proliferation Viral Process Peptidyl-tyrosine Phosphorylation Megakaryocyte Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Dendrite Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Lamellipodium Morphogenesis
Pathways		Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) White matter hyperintensity burden ( 25663218)
Interacting Genes		30 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CRKL DNMBP ENAH FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17	29 interacting genes: ABL1 APBB1 CACNA1A CUL2 CYFIP2 ENAH EPS8 EPS8L1 EVL GAS7 HSPA8 MINK1 NCK1 NCK2 NCKAP1 NEB NIN PAK2 PCM1 PRPF40A SOS1 SOS2 SPTA1 SPTAN1 SRRM1 TCERG1 VASP WASF1 WASF2
Entrez ID		51466	10006
HPRD ID		10942	04336
Ensembl ID		ENSG00000196405	ENSG00000136754
Uniprot IDs		A0A024R6K5 Q9UI08	A0A0A0MRT6 B6VEX3 B6VEX4 B6VEX5 Q8IZP0
PDB IDs
Enriched GO Terms of Interacting Partners?
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