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THBS1 and KNG1
Number of citations of the paper that reports this interaction (PubMedID
9459346
)
1
Data Source:
HPRD
(in vivo)
THBS1
KNG1
Description
thrombospondin 1
kininogen 1
Image
GO Annotations
Cellular Component
Extracellular Region
Fibrinogen Complex
Extracellular Space
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
External Side Of Plasma Membrane
Cell Surface
Sarcoplasmic Reticulum
Secretory Granule
Extracellular Matrix
Platelet Alpha Granule
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Extracellular Region
Extracellular Space
Cell
Endoplasmic Reticulum Lumen
Plasma Membrane
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Molecular Function
Phosphatidylserine Binding
Fibronectin Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Fibroblast Growth Factor Binding
Low-density Lipoprotein Particle Binding
Identical Protein Binding
Laminin Binding
Proteoglycan Binding
Transforming Growth Factor Beta Binding
Fibrinogen Binding
Collagen V Binding
Endopeptidase Inhibitor Activity
Cysteine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Heparin Binding
Zinc Ion Binding
Biological Process
Activation Of MAPK Activity
Response To Hypoxia
Negative Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Cell-matrix Adhesion
Sprouting Angiogenesis
Chronic Inflammatory Response
Platelet Degranulation
Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Negative Regulation Of Dendritic Cell Antigen Processing And Presentation
Inflammatory Response
Immune Response
Response To Unfolded Protein
Cell Cycle Arrest
Cell Adhesion
Positive Regulation Of Cell Proliferation
Response To Mechanical Stimulus
Response To Glucose
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport
Negative Regulation Of Nitric Oxide Mediated Signal Transduction
Negative Regulation Of CGMP-mediated Signaling
Negative Regulation Of Plasminogen Activation
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Fibroblast Migration
Cell Migration
Negative Regulation Of Angiogenesis
Peptide Cross-linking
Positive Regulation Of Blood Coagulation
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Magnesium Ion
Response To Progesterone
Negative Regulation Of Interleukin-12 Production
Positive Regulation Of Transforming Growth Factor Beta1 Production
Response To Testosterone
Cellular Response To Heat
Response To Endoplasmic Reticulum Stress
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Response To Drug
Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process
Positive Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Engulfment Of Apoptotic Cell
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Translation
Positive Regulation Of Angiogenesis
Behavioral Response To Pain
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Chemotaxis
Response To Calcium Ion
Negative Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Fibrinolysis
Cellular Response To Tumor Necrosis Factor
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Negative Regulation Of Sprouting Angiogenesis
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Endothelial Cell Chemotaxis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Platelet Degranulation
Inflammatory Response
Negative Regulation Of Cell Adhesion
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Blood Coagulation, Intrinsic Pathway
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Blood Coagulation
Vasodilation
Positive Regulation Of Apoptotic Process
Post-translational Protein Modification
Cellular Protein Metabolic Process
Negative Regulation Of Proteolysis
Pathways
Platelet degranulation
Signaling by PDGF
Integrin cell surface interactions
Syndecan interactions
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (q) signalling events
G alpha (i) signalling events
Post-translational protein phosphorylation
Drugs
Zinc
Copper
Diseases
GWAS
Logical memory (immediate recall) in normal cognition (
29274321
)
Urate levels (
31578528
)
Activated partial thromboplastin time (
22703881
29403010
20303064
)
Adiponectin levels (
20876611
)
Blood metabolite levels (
24816252
)
Blood protein levels (
30072576
29875488
28240269
)
Estimated glomerular filtration rate (
31152163
31015462
31451708
30604766
)
Factor XI (
28053049
)
Glomerular filtration rate (
29403010
)
Neuropathic pain in head and neck cancer (
29884837
)
Plasma renin activity levels (
25477429
)
Small vessel stroke (
29123153
)
Thrombosis (
26908601
)
Interacting Genes
40 interacting genes:
CALCR
CALR
CD36
CD47
CFH
COL1A1
COL2A1
COL3A1
COL4A1
COL5A1
COL7A1
CORO1A
CTSG
DCN
DHFR
ELANE
F2
FGA
FGF2
FN1
HRG
IGFBP5
ITGB3
JAG1
KNG1
LAMB3
LRP1
LRP2
LRP5
MMP2
MMP9
MTDH
PDGFB
PLG
SCARB2
SPARC
TFPI
TGFB1
TNFAIP6
TNFRSF11B
28 interacting genes:
AGT
APP
CAPN1
CAPN2
CD93
CPN1
CTSG
CTSK
CTSL
CTSS
ECE1
ELANE
F11
F2
FTL
GP1BA
HABP2
ITGB2
KLK1
KLKB1
KRT1
MEP1A
PLAUR
PLG
PREP
RXFP4
THBS1
VTN
Entrez ID
7057
3827
HPRD ID
01765
01970
Ensembl ID
ENSG00000137801
ENSG00000113889
Uniprot IDs
P07996
P01042
PDB IDs
1LSL
1UX6
1Z78
1ZA4
2ERF
2ES3
2OUH
2OUJ
3R6B
5FOE
1NY2
2WOK
4ASQ
4ASR
4ECB
4ECC
5I25
6F27
6F3V
6F3W
6F3X
6F3Y
Enriched GO Terms of Interacting Partners
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