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THBS1 and FGA
Number of citations of the paper that reports this interaction (PubMedID
9867861
)
10
Data Source:
HPRD
(in vitro)
THBS1
FGA
Description
thrombospondin 1
fibrinogen alpha chain
Image
GO Annotations
Cellular Component
Extracellular Region
Fibrinogen Complex
Extracellular Space
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
External Side Of Plasma Membrane
Cell Surface
Sarcoplasmic Reticulum
Secretory Granule
Extracellular Matrix
Platelet Alpha Granule
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Extracellular Region
Fibrinogen Complex
Extracellular Space
Endoplasmic Reticulum Lumen
Plasma Membrane
Cell Cortex
External Side Of Plasma Membrane
Cell Surface
Platelet Alpha Granule
Platelet Alpha Granule Lumen
Synapse
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Extracellular Vesicle
Molecular Function
Phosphatidylserine Binding
Fibronectin Binding
Integrin Binding
Extracellular Matrix Structural Constituent
Calcium Ion Binding
Protein Binding
Heparin Binding
Fibroblast Growth Factor Binding
Low-density Lipoprotein Particle Binding
Identical Protein Binding
Laminin Binding
Proteoglycan Binding
Transforming Growth Factor Beta Binding
Fibrinogen Binding
Collagen V Binding
Signaling Receptor Binding
Structural Molecule Activity
Extracellular Matrix Structural Constituent
Protein Binding
Metal Ion Binding
Cell Adhesion Molecule Binding
Biological Process
Activation Of MAPK Activity
Response To Hypoxia
Negative Regulation Of Endothelial Cell Proliferation
Negative Regulation Of Cell-matrix Adhesion
Sprouting Angiogenesis
Chronic Inflammatory Response
Platelet Degranulation
Negative Regulation Of Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Negative Regulation Of Dendritic Cell Antigen Processing And Presentation
Inflammatory Response
Immune Response
Response To Unfolded Protein
Cell Cycle Arrest
Cell Adhesion
Positive Regulation Of Cell Proliferation
Response To Mechanical Stimulus
Response To Glucose
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport
Negative Regulation Of Nitric Oxide Mediated Signal Transduction
Negative Regulation Of CGMP-mediated Signaling
Negative Regulation Of Plasminogen Activation
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Fibroblast Migration
Cell Migration
Negative Regulation Of Angiogenesis
Peptide Cross-linking
Positive Regulation Of Blood Coagulation
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Magnesium Ion
Response To Progesterone
Negative Regulation Of Interleukin-12 Production
Positive Regulation Of Transforming Growth Factor Beta1 Production
Response To Testosterone
Cellular Response To Heat
Response To Endoplasmic Reticulum Stress
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Response To Drug
Positive Regulation Of Tumor Necrosis Factor Biosynthetic Process
Positive Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Engulfment Of Apoptotic Cell
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Translation
Positive Regulation Of Angiogenesis
Behavioral Response To Pain
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Chemotaxis
Response To Calcium Ion
Negative Regulation Of Focal Adhesion Assembly
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Fibrinolysis
Cellular Response To Tumor Necrosis Factor
Cellular Response To Growth Factor Stimulus
Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Negative Regulation Of Sprouting Angiogenesis
Positive Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Endothelial Cell Chemotaxis
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Platelet Degranulation
Cell-matrix Adhesion
Blood Coagulation
Extracellular Matrix Organization
Plasminogen Activation
Positive Regulation Of Heterotypic Cell-cell Adhesion
Cellular Protein-containing Complex Assembly
Fibrinolysis
Induction Of Bacterial Agglutination
Post-translational Protein Modification
Cellular Protein Metabolic Process
Innate Immune Response
Positive Regulation Of Vasoconstriction
Positive Regulation Of Exocytosis
Positive Regulation Of Protein Secretion
Protein Polymerization
Response To Calcium Ion
Protein-containing Complex Assembly
Positive Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Blood Coagulation, Common Pathway
Blood Coagulation, Fibrin Clot Formation
Positive Regulation Of Peptide Hormone Secretion
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
Platelet degranulation
Signaling by PDGF
Integrin cell surface interactions
Syndecan interactions
Defective B3GALTL causes Peters-plus syndrome (PpS)
O-glycosylation of TSR domain-containing proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Platelet degranulation
Common Pathway of Fibrin Clot Formation
Integrin cell surface interactions
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Regulation of TLR by endogenous ligand
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Post-translational protein phosphorylation
Signaling downstream of RAS mutants
Amyloid fiber formation
Drugs
Alteplase
Reteplase
Anistreplase
Tenecteplase
Sucralfate
Zinc
Alfimeprase
Ancrod
EP-2104R
Prothrombin
Anti-inhibitor coagulant complex
Diseases
Afibrinogenemia; Dysfibrinogenemia
Inherited thrombophilia
Familial amyloidosis
GWAS
Logical memory (immediate recall) in normal cognition (
29274321
)
Urate levels (
31578528
)
D-dimer levels (
21502573
)
Fibrinogen (
20031577
21757653
)
Ischemic stroke (
29531354
)
Stroke (
29531354
)
Venous thromboembolism (
21980494
)
Interacting Genes
40 interacting genes:
CALCR
CALR
CD36
CD47
CFH
COL1A1
COL2A1
COL3A1
COL4A1
COL5A1
COL7A1
CORO1A
CTSG
DCN
DHFR
ELANE
F2
FGA
FGF2
FN1
HRG
IGFBP5
ITGB3
JAG1
KNG1
LAMB3
LRP1
LRP2
LRP5
MMP2
MMP9
MTDH
PDGFB
PLG
SCARB2
SPARC
TFPI
TGFB1
TNFAIP6
TNFRSF11B
19 interacting genes:
AGTRAP
APP
CDH5
F13A1
F2
FGB
FGG
HRG
ITGA2B
ITGB3
MEOX2
NID1
PLAT
PRRC2A
RAB14
SERPINA5
SERPINF2
THBS1
UBC
Entrez ID
7057
2243
HPRD ID
01765
00619
Ensembl ID
ENSG00000137801
ENSG00000171560
Uniprot IDs
P07996
P02671
PDB IDs
1LSL
1UX6
1Z78
1ZA4
2ERF
2ES3
2OUH
2OUJ
3R6B
5FOE
1BBR
1DM4
1FPH
1FZA
1FZB
1FZC
1FZD
1FZE
1FZF
1FZG
1LT9
1LTJ
1N86
1N8E
1RE3
1RE4
1RF0
1RF1
1YCP
2A45
2FFD
2H43
2HLO
2HOD
2HPC
2OYH
2OYI
2Q9I
2XNX
2XNY
2Z4E
3AT0
3BVH
3E1I
3GHG
3H32
3HUS
4F27
5CFA
Enriched GO Terms of Interacting Partners
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