CXCR1 and CXCL2

Number of citations of the paper that reports this interaction (PubMedID 9260277)
7

Data Source:
HPRD (in vivo, in vitro)

		CXCR1	CXCL2
Description		C-X-C motif chemokine receptor 1	C-X-C motif chemokine ligand 2
Image
GO Annotations	Cellular Component	Cell Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane	Extracellular Region Extracellular Space
	Molecular Function	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding Interleukin-8 Binding	Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding
	Biological Process	Dendritic Cell Chemotaxis Chemotaxis Immune Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Neutrophil Degranulation Cell Chemotaxis Chemokine-mediated Signaling Pathway	Response To Molecule Of Bacterial Origin Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Leukocyte Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		Ketoprofen
Diseases
GWAS		Diffusing capacity of carbon monoxide ( 30694715) Idiopathic intracranial hypertension ( 29608535) Inflammatory bowel disease ( 28067908 23128233) Neutrophil count ( 29403010) Smooth-surface caries ( 23470693) White blood cell count ( 29403010)	Eosinophil percentage of granulocytes ( 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 27863252) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 29403010 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 29403010 27863252 21738479) White blood cell types ( 21738478)
Interacting Genes		16 interacting genes: ADRA1A CDK1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 GNA14 GNA15 GNAI2 PDCD6IP PPBP TUBA1A UBE2C	5 interacting genes: CXCR1 CXCR2 EPS8 PIK3R1 PLG
Entrez ID		3577	2920
HPRD ID		00908	00741
Ensembl ID		ENSG00000163464	ENSG00000081041
Uniprot IDs		P25024	A0A024RDD9 P19875
PDB IDs		1ILP 1ILQ 2LNL	1QNK 5OB5
Enriched GO Terms of Interacting Partners?
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