CXCR1 and CXCL5

Number of citations of the paper that reports this interaction (PubMedID 8702798)
86

Data Source:
HPRD (in vivo)

		CXCR1	CXCL5
Description		C-X-C motif chemokine receptor 1	C-X-C motif chemokine ligand 5
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GO Annotations	Cellular Component	Cell Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane	Extracellular Region Extracellular Space
	Molecular Function	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding Interleukin-8 Binding	Chemokine Activity Identical Protein Binding CXCR Chemokine Receptor Binding
	Biological Process	Dendritic Cell Chemotaxis Chemotaxis Immune Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Neutrophil Degranulation Cell Chemotaxis Chemokine-mediated Signaling Pathway	Chemotaxis Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Neutrophil Chemotaxis Leukocyte Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Ketoprofen
Diseases
GWAS		Diffusing capacity of carbon monoxide ( 30694715) Idiopathic intracranial hypertension ( 29608535) Inflammatory bowel disease ( 28067908 23128233) Neutrophil count ( 29403010) Smooth-surface caries ( 23470693) White blood cell count ( 29403010)	Blood protein levels ( 30072576) CXCL5 levels ( 25147954) Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		16 interacting genes: ADRA1A CDK1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 GNA14 GNA15 GNAI2 PDCD6IP PPBP TUBA1A UBE2C	5 interacting genes: ACKR1 CXCR1 CXCR2 MMP9 NOTCH2NLA
Entrez ID		3577	6374
HPRD ID		00908	08976
Ensembl ID		ENSG00000163464	ENSG00000163735
Uniprot IDs		P25024	P42830 Q6I9S7
PDB IDs		1ILP 1ILQ 2LNL	2MGS
Enriched GO Terms of Interacting Partners?
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