CXCR1 and CXCL3

Number of citations of the paper that reports this interaction (PubMedID 8702798)
86

Data Source:
HPRD (in vivo, in vitro)

		CXCR1	CXCL3
Description		C-X-C motif chemokine receptor 1	C-X-C motif chemokine ligand 3
Image			No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane	Extracellular Region Extracellular Space
	Molecular Function	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding Interleukin-8 Binding	Chemokine Activity CXCR Chemokine Receptor Binding
	Biological Process	Dendritic Cell Chemotaxis Chemotaxis Immune Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Neutrophil Degranulation Cell Chemotaxis Chemokine-mediated Signaling Pathway	Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Neutrophil Chemotaxis Leukocyte Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs		Ketoprofen
Diseases
GWAS		Diffusing capacity of carbon monoxide ( 30694715) Idiopathic intracranial hypertension ( 29608535) Inflammatory bowel disease ( 28067908 23128233) Neutrophil count ( 29403010) Smooth-surface caries ( 23470693) White blood cell count ( 29403010)	Inflammatory bowel disease ( 23128233) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		16 interacting genes: ADRA1A CDK1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 GNA14 GNA15 GNAI2 PDCD6IP PPBP TUBA1A UBE2C	2 interacting genes: CXCR1 CXCR2
Entrez ID		3577	2921
HPRD ID		00908	00742
Ensembl ID		ENSG00000163464	ENSG00000163734
Uniprot IDs		P25024	P19876
PDB IDs		1ILP 1ILQ 2LNL
Enriched GO Terms of Interacting Partners?
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