CXCR1 and GNA15

Number of citations of the paper that reports this interaction (PubMedID 9843397)
13

Data Source:
HPRD (in vivo)

		CXCR1	GNA15
Description		C-X-C motif chemokine receptor 1	G protein subunit alpha 15
Image			No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane	Cell Heterotrimeric G-protein Complex Plasma Membrane Synapse
	Molecular Function	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding Interleukin-8 Binding	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Dendritic Cell Chemotaxis Chemotaxis Immune Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Neutrophil Degranulation Cell Chemotaxis Chemokine-mediated Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Platelet Activation Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation	Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs)
Drugs		Ketoprofen
Diseases
GWAS		Diffusing capacity of carbon monoxide ( 30694715) Idiopathic intracranial hypertension ( 29608535) Inflammatory bowel disease ( 28067908 23128233) Neutrophil count ( 29403010) Smooth-surface caries ( 23470693) White blood cell count ( 29403010)	Glucose homeostasis traits ( 25524916) Heart failure ( 20445134)
Interacting Genes		16 interacting genes: ADRA1A CDK1 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR2 GNA14 GNA15 GNAI2 PDCD6IP PPBP TUBA1A UBE2C	19 interacting genes: ADRB2 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRK2 GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1
Entrez ID		3577	2769
HPRD ID		00908	00760
Ensembl ID		ENSG00000163464	ENSG00000060558
Uniprot IDs		P25024	P30679
PDB IDs		1ILP 1ILQ 2LNL
Enriched GO Terms of Interacting Partners?
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