CXCL2 and EPS8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CXCL2	EPS8
Description		C-X-C motif chemokine ligand 2	epidermal growth factor receptor pathway substrate 8
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Brush Border Cell Cortex Postsynaptic Density NMDA Selective Glutamate Receptor Complex Cell Junction Growth Cone Vesicle Stereocilium Stereocilium Tip Ruffle Membrane Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding	Actin Binding Protein Binding Rac Guanyl-nucleotide Exchange Factor Activity Signaling Adaptor Activity Rac GTPase Binding
	Biological Process	Response To Molecule Of Bacterial Origin Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis Leukocyte Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide	Rho Protein Signal Transduction Adult Locomotory Behavior Regulation Of Cell Shape Positive Regulation Of Signal Transduction Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Actin Cytoskeleton Reorganization Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Ruffle Assembly Cellular Response To Leukemia Inhibitory Factor
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Eosinophil percentage of granulocytes ( 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 27863252) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 29403010 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 29403010 27863252 21738479) White blood cell types ( 21738478)	Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)
Interacting Genes		5 interacting genes: CXCR1 CXCR2 EPS8 PIK3R1 PLG	61 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XAGE2 XRCC6 ZZZ3
Entrez ID		2920	2059
HPRD ID		00741	02563
Ensembl ID		ENSG00000081041	ENSG00000151491
Uniprot IDs		A0A024RDD9 P19875	B4E3T6 Q12929
PDB IDs		1QNK 5OB5	2E8M
Enriched GO Terms of Interacting Partners?
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